Detailed information of TA system TA055110

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1714834..1715054
• Replicon: chromosome
• Accession: NZ_CP011848
• Organism: Clostridioides difficile strain DSM 27640

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: Q183Z5
• Locus tag: CDIF27640_RS08325
• Protein ID: WP_003429855.1
• Coordinates: 1714834..1714995 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1714915..1715054 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF27640_RS08290	1710691..1711128	+	438	WP_009888839.1	hypothetical protein	-
CDIF27640_RS08295	1711121..1711297	+	177	WP_009888840.1	hypothetical protein	-
CDIF27640_RS08300	1711298..1712608	+	1311	WP_009893136.1	phage tail sheath family protein	-
CDIF27640_RS08305	1712625..1713095	+	471	WP_009888842.1	phage tail tube protein	-
CDIF27640_RS08310	1713154..1713981	+	828	WP_009888843.1	hypothetical protein	-
CDIF27640_RS08315	1714053..1714493	+	441	WP_003429853.1	phage portal protein	-
CDIF27640_RS08325	1714834..1714995	+	162	WP_003429855.1	hypothetical protein	Toxin
-	1714915..1715054	-	140	NuclAT_1	-	Antitoxin
-	1714915..1715054	-	140	NuclAT_2	-	Antitoxin
-	1715399..1715447	-	49	NuclAT_4	-	-
-	1715399..1715447	-	49	NuclAT_5	-	-
CDIF27640_RS08330	1716332..1716520	+	189	WP_003429858.1	hypothetical protein	-
CDIF27640_RS08335	1716639..1717505	+	867	WP_009888845.1	hypothetical protein	-
CDIF27640_RS08345	1718370..1718897	+	528	WP_009888847.1	DUF4352 domain-containing protein	-
CDIF27640_RS08350	1719035..1719802	+	768	WP_009888848.1	DUF4428 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_013316 Clostridium difficile R20291 Prophage TA024266 1671047..1738184 0	inside	Prophage	-	-	1681045..1747482	66437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6120.42 Da
• Isoelectric Point: 10.8938

>T55110 WP_003429855.1 NZ_CP011848:1714834-1714995 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Nucleotide

• Length: 162 bp

>T55110 NZ_CP011848:1714834-1714995 [Clostridioides difficile]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCACAAATTTAAAT
AA

Antitoxin

Nucleotide

• Length: 140 bp

>AT55110 NZ_CP011848:c1715054-1714915 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGACAGTAGAGTGAAGTTCATAATTTAAACAATTAGTAATTATTTAAATTTGTGGAACTT
GATTTTAAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVN2

Antitoxin