Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP   Type   Regulator
Locus tag   AAYT23_RS07635 Genome accession   NZ_CP154877
Coordinates   1512510..1514489 (-) Length   659 a.a.
NCBI ID   WP_000614538.1    Uniprot ID   A0A0B7L145
Organism   Streptococcus pneumoniae strain 20234295     
Function   require for competence development; phosphorylate ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1507510..1519489
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAYT23_RS07605 (AAYT23_07585) - 1507605..1508879 (-) 1275 WP_000704388.1 hydroxymethylglutaryl-CoA reductase, degradative -
  AAYT23_RS07610 (AAYT23_07590) - 1508879..1510051 (-) 1173 WP_000151964.1 hydroxymethylglutaryl-CoA synthase -
  AAYT23_RS07615 (AAYT23_07595) - 1510182..1510430 (-) 249 WP_001813143.1 hypothetical protein -
  AAYT23_RS07620 (AAYT23_07600) - 1510498..1511124 (-) 627 Protein_1506 IS5 family transposase -
  AAYT23_RS07625 (AAYT23_07605) - 1511186..1511635 (-) 450 WP_000176924.1 threonine/serine exporter family protein -
  AAYT23_RS07630 (AAYT23_07610) - 1511637..1512395 (-) 759 WP_000392880.1 threonine/serine exporter family protein -
  AAYT23_RS07635 (AAYT23_07615) stkP 1512510..1514489 (-) 1980 WP_000614538.1 serine/threonine-protein kinase StkP Regulator
  AAYT23_RS07640 (AAYT23_07620) - 1514486..1515226 (-) 741 WP_000406247.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  AAYT23_RS07645 (AAYT23_07625) rsmB 1515241..1516554 (-) 1314 WP_001813140.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  AAYT23_RS07650 (AAYT23_07630) fmt 1516547..1517482 (-) 936 WP_000163690.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 659 a.a.        Molecular weight: 72288.81 Da        Isoelectric Point: 9.0945

>NTDB_id=994460 AAYT23_RS07635 WP_000614538.1 1512510..1514489(-) (stkP) [Streptococcus pneumoniae strain 20234295]
MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIG
EEDGQQYLAMEYVAGLDLKRYIKEHYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQKPLPSVIAENPSVP
QALENVIIKATAKKLTNRYRSVSEMYVDLSSSLSYNRRNESKLIFDETSKADTKTLPKVSQSTLTSIPKVQAQTEHKSIK
NPSQAVTEETYQPQAPKKHRFKMRYLILLASLVLVAASLIWILSRTPATIAIPDVAGQTVAEAKATLKKANFEIGEEKTE
ASEKVEEGRIIRTDPGAGTGRKEGTKINLVVSSGKQSFQISNYVGRKSSDVIAELKEKKVPDNLIKIEEEESNESEAGTV
LKQSLPEGTTYDLSKATQIVLTVAKKATTIQLGNYIGRNSTEVISELKQKKVPENLIKIEEEESSESEPGTIMKQSPGAG
TTYDVSKPTQIVLTVAKKVTSVAMPSYIGSSLEFTKNNLIQIVGIKEANIEVVEVTTAPAGSAEGMVVEQSPRAGEKVDL
NKTRVKISIYKPKTTSATP

Nucleotide


Download         Length: 1980 bp        

>NTDB_id=994460 AAYT23_RS07635 WP_000614538.1 1512510..1514489(-) (stkP) [Streptococcus pneumoniae strain 20234295]
ATGATCCAAATCGGCAAGATTTTTGCCGGACGCTATCGGATTGTCAAACAGATTGGTCGAGGAGGTATGGCGGATGTCTA
CCTAGCCAAAGACTTAATCTTAGATGGGGAAGAAGTGGCAGTGAAGGTTCTGAGGACCAACTACCAGACGGACCCGATAG
CTGTAGCTCGTTTTCAGCGTGAAGCGAGAGCTATGGCAGATCTAGACCATCCTCATATCGTTCGGATAACAGATATTGGT
GAGGAAGACGGTCAACAGTATCTTGCAATGGAGTATGTTGCTGGACTAGACCTCAAACGCTATATCAAGGAACATTATCC
TCTTTCTAATGAAGAAGCAGTCCGTATCATGGGACAAATCCTCCTAGCCATGCGTTTGGCCCATACCAGAGGAATTGTTC
ACAGGGACTTGAAACCTCAAAATATCCTTTTGACACCAGATGGGACTGCCAAGGTCACAGACTTTGGGATTGCTGTAGCC
TTTGCAGAGACAAGTCTGACCCAGACTAACTCGATGTTGGGCTCAGTTCATTACTTGTCCCCAGAGCAGGCGCGTGGTTC
GAAAGCGACTGTGCAGAGTGATATCTATGCTATGGGGATTATTTTCTATGAGATGTTGACAGGCCATATCCCTTATGACG
GGGATAGCGCGGTGACCATTGCCCTCCAGCATTTCCAGAAACCCCTGCCGTCCGTTATTGCAGAAAATCCATCTGTACCT
CAGGCTTTAGAAAATGTTATTATCAAGGCAACTGCTAAAAAGTTGACCAATCGCTACCGCTCGGTTTCAGAGATGTATGT
GGACTTGTCTAGTAGCTTGTCCTACAATCGTAGAAATGAAAGTAAGTTAATCTTTGATGAAACGAGCAAGGCAGATACCA
AGACCTTGCCGAAGGTTTCTCAGAGTACCTTGACATCTATTCCTAAGGTTCAAGCGCAGACAGAACACAAATCAATCAAA
AACCCAAGCCAGGCTGTGACAGAGGAAACTTACCAACCACAAGCACCGAAAAAACATAGATTTAAGATGCGTTACCTGAT
TTTGTTGGCCAGCCTTGTATTGGTGGCAGCTTCTCTTATTTGGATACTATCCAGAACTCCTGCAACCATTGCCATTCCAG
ATGTGGCAGGTCAGACAGTTGCAGAGGCCAAGGCAACGCTCAAAAAAGCCAATTTTGAGATTGGTGAGGAGAAGACAGAG
GCTAGTGAAAAGGTGGAAGAAGGGCGGATTATCCGTACAGATCCTGGCGCTGGAACTGGTCGAAAAGAAGGAACGAAAAT
CAATTTGGTTGTCTCATCAGGCAAACAATCCTTCCAAATTAGTAATTATGTCGGCCGGAAATCCTCTGATGTCATTGCGG
AATTAAAAGAGAAAAAAGTTCCAGATAATTTGATTAAAATTGAGGAAGAAGAGTCCAATGAGAGTGAGGCTGGAACGGTC
CTGAAGCAAAGTCTACCAGAAGGTACGACCTATGACTTGAGTAAGGCAACTCAAATTGTTTTGACAGTAGCTAAAAAAGC
TACGACGATTCAATTAGGGAACTATATTGGACGGAACTCTACAGAAGTAATCTCAGAACTCAAGCAGAAGAAGGTTCCTG
AGAATTTGATTAAGATAGAGGAAGAAGAGTCCAGCGAAAGCGAACCAGGAACGATTATGAAACAAAGTCCAGGTGCCGGA
ACGACTTATGATGTGAGTAAACCTACTCAAATTGTCTTGACAGTAGCTAAAAAAGTTACAAGTGTTGCCATGCCGAGTTA
CATTGGTTCCAGCTTGGAGTTTACTAAGAACAATTTGATTCAAATTGTTGGGATTAAGGAAGCTAATATAGAAGTTGTAG
AAGTGACGACAGCGCCTGCAGGTAGTGCAGAAGGCATGGTTGTTGAACAAAGTCCTAGAGCAGGTGAAAAGGTAGACCTC
AATAAGACTAGAGTCAAGATTTCAATCTACAAACCTAAAACAACTTCAGCTACTCCTTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-227)

PASTA domain (PASTA)

(440-505)

PASTA domain (PASTA)

(582-651)

PASTA domain (PASTA)

(513-577)

PASTA domain (PASTA)

(371-432)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7L145

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP Streptococcus pneumoniae TIGR4

100

100

1
  stkP Streptococcus pneumoniae D39

99.545

100

0.995
  stkP Streptococcus pneumoniae R6

99.545

100

0.995
  stkP Streptococcus pneumoniae Rx1

99.393

100

0.994
  pknB Streptococcus mutans UA159

52.65

88.771

0.467
  stkP/pknB Streptococcus salivarius strain HSISS4

51.807

88.164

0.457

Multiple sequence alignment