Detailed information NTG0097626

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: R8522_RS02535
• Genome accession: NZ_AP026916
• Coordinates: 494027..494764 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219122.1
• Uniprot ID: A0A0I5XJR5
• Organism: Streptococcus pneumoniae strain PZ900700006
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 489027..499764

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8522_RS02500 (PC0006_05080)	-	489912..490196 (-)	285	WP_025169639.1	hypothetical protein	-
R8522_RS02505 (PC0006_05090)	-	490358..490645 (-)	288	WP_000777760.1	hypothetical protein	-
R8522_RS02510 (PC0006_05100)	-	490655..491065 (-)	411	WP_001278301.1	HIT family protein	-
R8522_RS02515 (PC0006_05110)	pptA	491133..491864 (+)	732	WP_000889919.1	ABC transporter ATP-binding protein	Regulator
R8522_RS02520 (PC0006_05120)	-	491861..492910 (+)	1050	WP_000653767.1	ABC transporter permease	-
R8522_RS02525 (PC0006_05130)	-	493078..493407 (-)	330	WP_000132575.1	hypothetical protein	-
R8522_RS02530 (PC0006_05140)	-	493684..494022 (+)	339	WP_000682133.1	LytTR family DNA-binding domain-containing protein	-
R8522_RS02535 (PC0006_05150)	comE/blpR	494027..494764 (+)	738	WP_001219122.1	LytTR family DNA-binding domain-containing protein	Regulator
R8522_RS02540 (PC0006_05160)	-	494777..496117 (+)	1341	WP_050123659.1	sensor histidine kinase	-
R8522_RS02545 (PC0006_05170)	blpC	496188..496316 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
R8522_RS02550 (PC0006_05180)	-	496373..497734 (-)	1362	WP_050122537.1	bacteriocin secretion accessory protein	-
R8522_RS02555 (PC0006_05190)	comA/nlmT	497745..499421 (-)	1677	WP_196302068.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28766.95 Da
• Isoelectric Point: 6.4140

>NTDB_id=97626 R8522_RS02535 WP_001219122.1 494027..494764(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700006]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=97626 R8522_RS02535 WP_001219122.1 494027..494764(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700006]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGACATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A0I5XJR5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38