Detailed information NTG0084122

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: LLC_RS02790
• Genome accession: NZ_AP024222
• Coordinates: 545782..546474 (-)
• Length: 230 a.a.
• NCBI ID: WP_011676631.1
• Uniprot ID: A0A0M2ZTN8
• Organism: Lactococcus cremoris strain EPSC
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 540782..551474

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLC_RS02770 (LLC_05780)	murD	540926..542275 (-)	1350	WP_021211936.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-
LLC_RS02775 (LLC_05790)	-	542444..542785 (-)	342	WP_011676628.1	P-II family nitrogen regulator	-
LLC_RS02780 (LLC_05800)	-	542870..544111 (-)	1242	WP_015082643.1	ammonium transporter	-
LLC_RS02785 (LLC_05810)	covS	544297..545769 (-)	1473	WP_021211938.1	HAMP domain-containing histidine kinase	Regulator
LLC_RS02790 (LLC_05820)	covR	545782..546474 (-)	693	WP_011676631.1	response regulator transcription factor	Regulator
LLC_RS02795 (LLC_05830)	-	546630..547160 (-)	531	WP_011834860.1	YceD family protein	-
LLC_RS02800 (LLC_05840)	-	547293..547538 (-)	246	WP_011676633.1	type B 50S ribosomal protein L31	-
LLC_RS02805	-	547862..548224 (-)	363	Protein_561	TIGR02328 family protein	-
LLC_RS02810 (LLC_05860)	-	548461..549372 (-)	912	WP_021212488.1	CHAP domain-containing protein	-
LLC_RS13915 (LLC_05870)	-	549465..549605 (-)	141	WP_232034968.1	hypothetical protein	-
LLC_RS13920 (LLC_05880)	-	549697..550137 (-)	441	WP_232034967.1	metallophosphoesterase	-
LLC_RS02820 (LLC_05890)	-	550175..551350 (-)	1176	WP_003138385.1	IS256-like element IS905 family transposase	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26654.33 Da
• Isoelectric Point: 5.1273

>NTDB_id=84122 LLC_RS02790 WP_011676631.1 545782..546474(-) (covR) [Lactococcus cremoris strain EPSC]
MASKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=84122 LLC_RS02790 WP_011676631.1 545782..546474(-) (covR) [Lactococcus cremoris strain EPSC]
ATGGCATCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCTCGTTTCGTCTCATTAGAATTAGAGCATGAAGG
CTATGCCACTGAGATTAAAGATAACGGACGTTCTGGGCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGATGGTTTTGAAGTTGCCCGCCGTTTGCGCAAAGAAAAAGATACTCCAATTATTATGATG
ACCGCGCGTGATTCAACAATGGACCGTGTTGCCGGTCTTGATATTGGAGCAGATGATTATATTACTAAGCCTTTTGCGAT
TGAAGAACTTTTGGCTCGTGTTCGTGCATTCTTCCGTCGTGAAGAACATGGTCATGCTGTAGAACGTGCTGAAAACACTT
CTTTTCGTGATCTTGTAATTGACAAAACAAATCGTACCGTTCACCGCGGTAAAAAAGTAATTGATTTGACGCGTCGTGAA
TACGATCTTCTTTTGACGTTGATGCAAAATGTTGGGGATGTTGTCACTCGCGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACGGAAACAAATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACA
GCTATATTCAAACCGTTCGTGGTTTGGGTTATGTGATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: A0A0M2ZTN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361