Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   M1GAS476_RS01625 Genome accession   NC_020540
Coordinates   311195..311881 (+) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes M1 476     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 306195..316881
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M1GAS476_RS01600 (M1GAS476_0341) ktrB 306337..307713 (-) 1377 WP_032459877.1 potassium uptake transporter channel subunit KtrB -
  M1GAS476_RS01605 (M1GAS476_0342) rsmG 307798..308511 (-) 714 WP_010921904.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  M1GAS476_RS01610 (M1GAS476_0343) - 308661..309218 (+) 558 WP_002985956.1 LemA family protein -
  M1GAS476_RS01615 (M1GAS476_0344) htpX 309265..310161 (+) 897 WP_002985953.1 zinc metalloprotease HtpX -
  M1GAS476_RS01620 (M1GAS476_0345) - 310395..310928 (+) 534 WP_011054200.1 YceD family protein -
  M1GAS476_RS01625 (M1GAS476_0346) covR 311195..311881 (+) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  M1GAS476_RS01630 (M1GAS476_0347) covS 311887..313389 (+) 1503 WP_015055916.1 two-component system sensor histidine kinase CovS -
  M1GAS476_RS01635 (M1GAS476_0348) nrdR 313604..314098 (+) 495 WP_002985941.1 transcriptional regulator NrdR -
  M1GAS476_RS01640 (M1GAS476_0349) - 314082..315257 (+) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -
  M1GAS476_RS01645 (M1GAS476_0350) dnaI 315258..316160 (+) 903 WP_002991016.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=57078 M1GAS476_RS01625 WP_002991052.1 311195..311881(+) (covR) [Streptococcus pyogenes M1 476]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=57078 M1GAS476_RS01625 WP_002991052.1 311195..311881(+) (covR) [Streptococcus pyogenes M1 476]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment