Detailed information    

insolico Bioinformatically predicted

Overview


Name   recA   Type   Machinery gene
Locus tag   VKP40_RS08620 Genome accession   NZ_CP142355
Coordinates   1734901..1736037 (-) Length   378 a.a.
NCBI ID   WP_002992179.1    Uniprot ID   A0A4Q1QZP2
Organism   Streptococcus pyogenes strain A946     
Function   homologous recombination (predicted from homology)   
Homologous recombination

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1726405..1754154 1734901..1736037 within 0


Gene organization within MGE regions


Location: 1726405..1754154
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP40_RS08570 (VKP40_08570) nrdG 1726405..1727019 (-) 615 WP_021775544.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  VKP40_RS08575 (VKP40_08575) - 1727034..1727528 (-) 495 WP_011055085.1 GNAT family N-acetyltransferase -
  VKP40_RS08580 (VKP40_08580) - 1727537..1728472 (-) 936 WP_111686419.1 Gfo/Idh/MocA family protein -
  VKP40_RS08585 (VKP40_08585) - 1728501..1728647 (-) 147 WP_002982210.1 hypothetical protein -
  VKP40_RS08590 (VKP40_08590) nrdD 1728829..1731027 (-) 2199 WP_002992831.1 anaerobic ribonucleoside-triphosphate reductase -
  VKP40_RS08595 (VKP40_08595) - 1731124..1732683 (-) 1560 WP_002992833.1 membrane protein -
  VKP40_RS08600 (VKP40_08600) - 1733096..1733401 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  VKP40_RS08605 (VKP40_08605) ruvX 1733413..1733832 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  VKP40_RS08610 (VKP40_08610) - 1733829..1734098 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  VKP40_RS08615 (VKP40_08615) spx 1734212..1734610 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  VKP40_RS08620 (VKP40_08620) recA 1734901..1736037 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  VKP40_RS08625 (VKP40_08625) cinA 1736126..1737397 (-) 1272 WP_002992182.1 competence/damage-inducible protein A Machinery gene
  VKP40_RS08630 (VKP40_08630) - 1737466..1738026 (-) 561 WP_002992183.1 DNA-3-methyladenine glycosylase I -
  VKP40_RS08635 (VKP40_08635) ruvA 1738036..1738632 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA -
  VKP40_RS08640 (VKP40_08640) - 1738634..1739854 (-) 1221 WP_002992187.1 MDR family MFS transporter -
  VKP40_RS08645 (VKP40_08645) mutL 1739865..1741847 (-) 1983 WP_326675770.1 DNA mismatch repair endonuclease MutL -
  VKP40_RS08650 (VKP40_08650) - 1741942..1743093 (-) 1152 WP_003058754.1 tyrosine-type recombinase/integrase -
  VKP40_RS08655 (VKP40_08655) - 1743342..1743485 (+) 144 WP_011185066.1 putative holin-like toxin -
  VKP40_RS08660 (VKP40_08660) - 1744334..1745101 (-) 768 WP_003058809.1 helix-turn-helix transcriptional regulator -
  VKP40_RS08665 (VKP40_08665) - 1745255..1745461 (+) 207 WP_002992503.1 helix-turn-helix transcriptional regulator -
  VKP40_RS08670 (VKP40_08670) - 1745495..1745683 (+) 189 Protein_1652 helix-turn-helix domain-containing protein -
  VKP40_RS08675 (VKP40_08675) - 1745714..1746121 (+) 408 WP_002992501.1 hypothetical protein -
  VKP40_RS08680 (VKP40_08680) - 1746134..1746256 (+) 123 WP_011285272.1 hypothetical protein -
  VKP40_RS08685 (VKP40_08685) - 1746537..1747058 (+) 522 WP_247456465.1 Rha family transcriptional regulator -
  VKP40_RS08690 (VKP40_08690) - 1747303..1747635 (+) 333 WP_002992497.1 hypothetical protein -
  VKP40_RS08695 (VKP40_08695) - 1747635..1747826 (+) 192 WP_027968868.1 hypothetical protein -
  VKP40_RS08700 (VKP40_08700) - 1747839..1748201 (+) 363 WP_000206026.1 hypothetical protein -
  VKP40_RS08705 (VKP40_08705) - 1748198..1748527 (+) 330 WP_000174505.1 hypothetical protein -
  VKP40_RS08710 (VKP40_08710) - 1748530..1748802 (+) 273 WP_000051914.1 hypothetical protein -
  VKP40_RS08715 (VKP40_08715) - 1748803..1749660 (+) 858 WP_011185073.1 primase alpha helix C-terminal domain-containing protein -
  VKP40_RS08720 (VKP40_08720) - 1749629..1751317 (+) 1689 WP_002992487.1 DNA primase family protein -
  VKP40_RS08725 (VKP40_08725) - 1751604..1751777 (+) 174 WP_109981952.1 DUF2758 domain-containing protein -
  VKP40_RS08730 (VKP40_08730) - 1751783..1751956 (+) 174 WP_011185075.1 hypothetical protein -
  VKP40_RS08735 (VKP40_08735) - 1751958..1752467 (+) 510 WP_011185076.1 hypothetical protein -
  VKP40_RS08740 (VKP40_08740) - 1752542..1753030 (+) 489 WP_002992480.1 hypothetical protein -
  VKP40_RS08745 (VKP40_08745) - 1753434..1753796 (+) 363 WP_002992136.1 DUF1492 domain-containing protein -
  VKP40_RS08750 (VKP40_08750) - 1753771..1754154 (+) 384 WP_011185077.1 ArpU family phage packaging/lysis transcriptional regulator -

Sequence


Protein


Download         Length: 378 a.a.        Molecular weight: 40631.23 Da        Isoelectric Point: 4.9004

>NTDB_id=925293 VKP40_RS08620 WP_002992179.1 1734901..1736037(-) (recA) [Streptococcus pyogenes strain A946]
MAKKLKKNEEITKKFGDERRKALDDALKNIEKDFGKGAVMRLGERAEQKVQVMSSGSLALDIALGAGGYPKGRIIEIYGP
ESSGKTTVALHAVAQAQKEGGIAAFIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVA
ALVPRAEIDGDIGDSHVGLQARMMSQAMRKLSASINKTKTIAIFINQLREKVGVMFGNPETTPGGRALKFYASVRLDVRG
TTQIKGTGDQKDSSIGKETKIKVVKNKVAPPFKVAEVEIMYGEGISRTGELVKIASDLDIIQKAGAWFSYNGEKIGQGSE
NAKRYLADHPQLFDEIDRKVRVKFGLLEESEEESAMAVASEETDDLALDLDNGIEIED

Nucleotide


Download         Length: 1137 bp        

>NTDB_id=925293 VKP40_RS08620 WP_002992179.1 1734901..1736037(-) (recA) [Streptococcus pyogenes strain A946]
TTGGCAAAAAAATTAAAAAAGAATGAAGAAATCACTAAGAAGTTTGGTGACGAACGTCGCAAAGCCCTTGATGATGCTTT
GAAAAATATTGAAAAAGATTTTGGTAAGGGCGCAGTGATGCGATTAGGAGAACGTGCAGAGCAAAAAGTTCAGGTTATGA
GTTCAGGAAGTCTAGCTCTTGATATTGCGCTTGGAGCTGGTGGTTATCCTAAAGGACGTATCATCGAAATCTATGGTCCA
GAGTCTTCCGGTAAAACGACTGTGGCTTTACATGCTGTAGCACAAGCTCAAAAAGAAGGTGGAATCGCAGCCTTTATCGA
TGCCGAGCATGCGCTTGATCCAGCTTATGCTGCTGCGCTTGGGGTTAATATTGATGAACTCCTCTTGTCTCAACCAGATT
CTGGAGAACAAGGACTTGAAATTGCAGGTAAATTGATTGATTCTGGTGCGGTTGATCTGGTTGTTGTCGATTCAGTAGCA
GCTTTAGTGCCACGTGCTGAAATTGATGGTGATATTGGCGATAGCCATGTCGGATTGCAAGCACGTATGATGAGTCAGGC
CATGCGTAAATTATCAGCTTCTATTAATAAAACAAAAACTATCGCTATCTTTATTAACCAATTGCGTGAAAAAGTTGGTG
TGATGTTTGGAAATCCTGAAACAACACCAGGTGGTCGAGCTTTGAAATTCTATGCTTCTGTTCGGTTGGATGTGCGTGGA
ACAACTCAAATTAAAGGAACTGGTGACCAAAAAGATAGCAGTATTGGTAAGGAGACCAAAATCAAGGTTGTTAAAAACAA
GGTCGCTCCGCCATTTAAGGTAGCAGAAGTTGAAATCATGTATGGGGAAGGTATTTCTCGTACAGGGGAGCTTGTGAAAA
TTGCTTCTGATTTGGACATTATCCAAAAAGCAGGTGCTTGGTTCTCTTATAATGGTGAGAAGATTGGCCAAGGTTCTGAA
AATGCTAAGCGTTATTTGGCCGATCATCCACAATTGTTTGATGAAATCGACCGTAAAGTACGTGTTAAATTTGGTTTGCT
TGAAGAAAGCGAAGAAGAATCTGCTATGGCAGTAGCATCAGAAGAAACCGATGATCTTGCTTTAGATTTAGATAATGGTA
TTGAAATTGAAGATTAA


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A4Q1QZP2

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  recA Streptococcus pyogenes NZ131

99.735

100

0.997

  recA Streptococcus mutans UA159

87.467

100

0.886

  recA Streptococcus mitis NCTC 12261

85.34

100

0.862

  recA Streptococcus pneumoniae Rx1

84.416

100

0.86

  recA Streptococcus pneumoniae D39

84.416

100

0.86

  recA Streptococcus pneumoniae R6

84.416

100

0.86

  recA Streptococcus pneumoniae TIGR4

84.416

100

0.86

  recA Streptococcus mitis SK321

85.302

100

0.86

  recA Lactococcus lactis subsp. cremoris KW2

78.754

93.386

0.735

  recA Latilactobacillus sakei subsp. sakei 23K

70.623

89.153

0.63

  recA Bacillus subtilis subsp. subtilis str. 168

68.085

87.037

0.593

  recA Acinetobacter baylyi ADP1

60

92.593

0.556

  recA Acinetobacter baumannii D1279779

59.49

93.386

0.556

  recA Riemerella anatipestifer ATCC 11845 = DSM 15868

62.018

89.153

0.553

  recA Neisseria gonorrhoeae MS11

60.058

90.741

0.545

  recA Neisseria gonorrhoeae MS11

60.058

90.741

0.545

  recA Neisseria gonorrhoeae strain FA1090

60.058

90.741

0.545

  recA Vibrio cholerae strain A1552

58.286

92.593

0.54

  recA Vibrio cholerae O1 biovar El Tor strain E7946

58.286

92.593

0.54

  recA Glaesserella parasuis strain SC1401

59.706

89.947

0.537

  recA Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539

62.539

85.45

0.534

  recA Pseudomonas stutzeri DSM 10701

56.897

92.063

0.524

  recA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.912

87.566

0.516

  recA Helicobacter pylori 26695

58.084

88.36

0.513

  recA Helicobacter pylori strain NCTC11637

58.084

88.36

0.513

  recA Ralstonia pseudosolanacearum GMI1000

57.831

87.831

0.508