Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   VKP40_RS08625 Genome accession   NZ_CP142355
Coordinates   1736126..1737397 (-) Length   423 a.a.
NCBI ID   WP_002992182.1    Uniprot ID   A0A660A3W1
Organism   Streptococcus pyogenes strain A946     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1726405..1754154 1736126..1737397 within 0


Gene organization within MGE regions


Location: 1726405..1754154
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP40_RS08570 (VKP40_08570) nrdG 1726405..1727019 (-) 615 WP_021775544.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  VKP40_RS08575 (VKP40_08575) - 1727034..1727528 (-) 495 WP_011055085.1 GNAT family N-acetyltransferase -
  VKP40_RS08580 (VKP40_08580) - 1727537..1728472 (-) 936 WP_111686419.1 Gfo/Idh/MocA family protein -
  VKP40_RS08585 (VKP40_08585) - 1728501..1728647 (-) 147 WP_002982210.1 hypothetical protein -
  VKP40_RS08590 (VKP40_08590) nrdD 1728829..1731027 (-) 2199 WP_002992831.1 anaerobic ribonucleoside-triphosphate reductase -
  VKP40_RS08595 (VKP40_08595) - 1731124..1732683 (-) 1560 WP_002992833.1 membrane protein -
  VKP40_RS08600 (VKP40_08600) - 1733096..1733401 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  VKP40_RS08605 (VKP40_08605) ruvX 1733413..1733832 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  VKP40_RS08610 (VKP40_08610) - 1733829..1734098 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  VKP40_RS08615 (VKP40_08615) spx 1734212..1734610 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  VKP40_RS08620 (VKP40_08620) recA 1734901..1736037 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  VKP40_RS08625 (VKP40_08625) cinA 1736126..1737397 (-) 1272 WP_002992182.1 competence/damage-inducible protein A Machinery gene
  VKP40_RS08630 (VKP40_08630) - 1737466..1738026 (-) 561 WP_002992183.1 DNA-3-methyladenine glycosylase I -
  VKP40_RS08635 (VKP40_08635) ruvA 1738036..1738632 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA -
  VKP40_RS08640 (VKP40_08640) - 1738634..1739854 (-) 1221 WP_002992187.1 MDR family MFS transporter -
  VKP40_RS08645 (VKP40_08645) mutL 1739865..1741847 (-) 1983 WP_326675770.1 DNA mismatch repair endonuclease MutL -
  VKP40_RS08650 (VKP40_08650) - 1741942..1743093 (-) 1152 WP_003058754.1 tyrosine-type recombinase/integrase -
  VKP40_RS08655 (VKP40_08655) - 1743342..1743485 (+) 144 WP_011185066.1 putative holin-like toxin -
  VKP40_RS08660 (VKP40_08660) - 1744334..1745101 (-) 768 WP_003058809.1 helix-turn-helix transcriptional regulator -
  VKP40_RS08665 (VKP40_08665) - 1745255..1745461 (+) 207 WP_002992503.1 helix-turn-helix transcriptional regulator -
  VKP40_RS08670 (VKP40_08670) - 1745495..1745683 (+) 189 Protein_1652 helix-turn-helix domain-containing protein -
  VKP40_RS08675 (VKP40_08675) - 1745714..1746121 (+) 408 WP_002992501.1 hypothetical protein -
  VKP40_RS08680 (VKP40_08680) - 1746134..1746256 (+) 123 WP_011285272.1 hypothetical protein -
  VKP40_RS08685 (VKP40_08685) - 1746537..1747058 (+) 522 WP_247456465.1 Rha family transcriptional regulator -
  VKP40_RS08690 (VKP40_08690) - 1747303..1747635 (+) 333 WP_002992497.1 hypothetical protein -
  VKP40_RS08695 (VKP40_08695) - 1747635..1747826 (+) 192 WP_027968868.1 hypothetical protein -
  VKP40_RS08700 (VKP40_08700) - 1747839..1748201 (+) 363 WP_000206026.1 hypothetical protein -
  VKP40_RS08705 (VKP40_08705) - 1748198..1748527 (+) 330 WP_000174505.1 hypothetical protein -
  VKP40_RS08710 (VKP40_08710) - 1748530..1748802 (+) 273 WP_000051914.1 hypothetical protein -
  VKP40_RS08715 (VKP40_08715) - 1748803..1749660 (+) 858 WP_011185073.1 primase alpha helix C-terminal domain-containing protein -
  VKP40_RS08720 (VKP40_08720) - 1749629..1751317 (+) 1689 WP_002992487.1 DNA primase family protein -
  VKP40_RS08725 (VKP40_08725) - 1751604..1751777 (+) 174 WP_109981952.1 DUF2758 domain-containing protein -
  VKP40_RS08730 (VKP40_08730) - 1751783..1751956 (+) 174 WP_011185075.1 hypothetical protein -
  VKP40_RS08735 (VKP40_08735) - 1751958..1752467 (+) 510 WP_011185076.1 hypothetical protein -
  VKP40_RS08740 (VKP40_08740) - 1752542..1753030 (+) 489 WP_002992480.1 hypothetical protein -
  VKP40_RS08745 (VKP40_08745) - 1753434..1753796 (+) 363 WP_002992136.1 DUF1492 domain-containing protein -
  VKP40_RS08750 (VKP40_08750) - 1753771..1754154 (+) 384 WP_011185077.1 ArpU family phage packaging/lysis transcriptional regulator -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45933.64 Da        Isoelectric Point: 4.7648

>NTDB_id=925294 VKP40_RS08625 WP_002992182.1 1736126..1737397(-) (cinA) [Streptococcus pyogenes strain A946]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRRDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPI
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKSITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
CYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=925294 VKP40_RS08625 WP_002992182.1 1736126..1737397(-) (cinA) [Streptococcus pyogenes strain A946]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGGAGTGATTTGGTCATTTTATGCGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAGAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGATCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATTACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATA
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGTCAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACGGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
TGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Competence-damaged protein (CinA)

(263-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A660A3W1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.267

100

0.693
  cinA Streptococcus mitis SK321

69.065

98.582

0.681
  cinA Streptococcus mitis NCTC 12261

68.585

98.582

0.676
  cinA Streptococcus pneumoniae TIGR4

67.626

98.582

0.667
  cinA Streptococcus pneumoniae Rx1

67.626

98.582

0.667
  cinA Streptococcus pneumoniae R6

67.626

98.582

0.667
  cinA Streptococcus pneumoniae D39

67.386

98.582

0.664
  cinA Streptococcus suis isolate S10

52.644

98.345

0.518
  cinA Bacillus subtilis subsp. subtilis str. 168

46.172

98.818

0.456