Detailed information NTG0051150

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: SIR_RS18185
• Genome accession: NC_022246
• Coordinates: 1751506..1753635 (-)
• Length: 709 a.a.
• NCBI ID: WP_021003252.1
• Uniprot ID: T1ZGZ9
• Organism: Streptococcus intermedius B196
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 1746506..1758635

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SIR_RS18155 (SIR_1653)	-	1746589..1747296 (-)	708	WP_003074030.1	L-ribulose-5-phosphate 4-epimerase	-
SIR_RS18160 (SIR_1654)	-	1747299..1748162 (-)	864	WP_021003249.1	L-ribulose-5-phosphate 3-epimerase	-
SIR_RS18165 (SIR_1655)	-	1748168..1748833 (-)	666	WP_021003250.1	3-keto-L-gulonate-6-phosphate decarboxylase UlaD	-
SIR_RS18170 (SIR_1656)	-	1748879..1749364 (-)	486	WP_021003251.1	PTS sugar transporter subunit IIA	-
SIR_RS18175 (SIR_1657)	-	1749566..1749847 (-)	282	WP_003074022.1	PTS sugar transporter subunit IIB	-
SIR_RS18180 (SIR_1658)	-	1749878..1751338 (-)	1461	WP_009569486.1	PTS ascorbate transporter subunit IIC	-
SIR_RS18185 (SIR_1659)	clpE	1751506..1753635 (-)	2130	WP_021003252.1	AAA family ATPase	Regulator
SIR_RS18190 (SIR_1660)	glmS	1754054..1755868 (-)	1815	WP_021003253.1	glutamine--fructose-6-phosphate transaminase (isomerizing)	-
SIR_RS18195 (SIR_1661)	-	1756258..1757457 (-)	1200	WP_021003254.1	acetate kinase	-
SIR_RS18200 (SIR_1662)	comGH	1757504..1758457 (-)	954	WP_021003255.1	class I SAM-dependent methyltransferase	Machinery gene

Sequence

Protein

• Length: 709 a.a.
• Molecular weight: 78991.23 Da
• Isoelectric Point: 4.8443

>NTDB_id=51150 SIR_RS18185 WP_021003252.1 1751506..1753635(-) (clpE) [Streptococcus intermedius B196]
MNNNYNNFDNMDDLFNQLMGRMGGFNSENRRYLINGREVTPEEFAQYRATGKLPKQVAEGQASQMQGQAGELKQDGILMK
LGRNLTEEARQDMLDPVIGRNKEIQETAEILSRRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIVSIDIS
GLEAGTQYRGSFEENIQNLVSEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRN
TILKNAALARRFNEVKVNAPSAEDTYKILQGIRDLYEKHHNVILPDDVLKAAVDFSIQYIPQRSLPDKAIDLVDVTAAHL
AAQHPVTDVHTVEREIAEQKKKQEAAVEKEDFETALNAKMRIEELEKKIENHTEDMKVTATVNDVAESVERMTGIPVSQM
GTSDIERLKEMNARLKTKVIGQNEAVEAVARAIRRNRAGFDEGNRPIGSFLFVGPTGVGKTELAKQLALDMFGTKEAIIR
LDMSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFK
NTVIIATSNAGFGYESFTGDEEKDRKIMDRLKPYFRPEFLNRFNAVIEFSHLGKEDLAEIVDLMLDEVNQTLAKKDIMLT
VTDAAKHYLAEEGYDEVMGVRPLRRVIEQQIRDKVTDYHLDHLDAKHLLAYLKDDELVIEEAKEHQTKK

Nucleotide

• Length: 2130 bp

>NTDB_id=51150 SIR_RS18185 WP_021003252.1 1751506..1753635(-) (clpE) [Streptococcus intermedius B196]
ATGAACAATAACTATAATAACTTTGATAATATGGATGATCTTTTCAATCAATTGATGGGAAGAATGGGTGGTTTTAACAG
TGAAAATCGGCGTTATCTTATCAATGGACGTGAAGTGACACCAGAAGAATTTGCACAATATCGTGCAACAGGTAAATTAC
CGAAGCAAGTAGCGGAAGGTCAGGCATCACAAATGCAAGGACAAGCAGGTGAGCTTAAACAAGATGGTATTTTAATGAAG
TTAGGGCGTAATTTGACAGAAGAAGCACGTCAAGATATGTTAGATCCTGTTATTGGACGCAATAAGGAAATTCAAGAAAC
GGCTGAAATTCTTTCTCGGCGGACGAAAAACAATCCAGTATTAGTCGGAGACGCTGGAGTTGGTAAGACTGCAGTTGTTG
AAGGTTTAGCGCAAGCGATTGTTAATGGAGATGTTCCTGCAGCCATTAAGAATAAAGAGATTGTTTCTATTGATATTTCT
GGTTTAGAAGCAGGGACACAGTATCGTGGTAGTTTTGAAGAAAATATTCAAAATTTAGTATCTGAAGTGAAAGAGGCTGG
CAATATCATTCTCTTCTTTGATGAAATTCATCAAATTCTCGGCGCTGGAAGCACAGGCGGTGATAGTGGATCAAAAGGTC
TAGCAGATATTTTGAAACCGGCTTTATCTCGTGGTGAACTGACAGTTATCGGTGCGACGACTCAGGATGAATATCGAAAT
ACCATTTTGAAGAATGCAGCTCTAGCTCGTCGCTTCAATGAAGTAAAAGTCAATGCCCCATCTGCAGAAGATACTTACAA
GATTTTGCAAGGAATTCGTGATTTATACGAAAAACACCACAATGTCATCTTGCCAGATGACGTGTTAAAAGCTGCCGTGG
ACTTCTCTATTCAATATATTCCACAACGCAGCTTGCCGGATAAAGCGATTGACCTGGTGGATGTGACAGCGGCTCATTTA
GCAGCTCAACATCCTGTTACAGATGTGCATACAGTGGAACGTGAAATTGCAGAGCAAAAGAAAAAGCAAGAAGCTGCGGT
TGAAAAAGAAGACTTTGAAACTGCTTTGAATGCCAAGATGCGTATTGAAGAGCTAGAAAAAAAGATTGAAAATCATACGG
AAGACATGAAGGTGACTGCAACTGTCAATGATGTAGCAGAATCTGTAGAACGTATGACGGGCATTCCTGTTTCCCAAATG
GGGACTAGTGATATTGAACGGTTGAAAGAGATGAATGCGCGATTGAAGACAAAAGTCATTGGACAAAACGAAGCAGTTGA
AGCAGTGGCGCGCGCTATTCGTCGGAATCGTGCAGGTTTTGATGAAGGAAATCGTCCGATTGGTAGCTTTCTCTTTGTTG
GCCCAACTGGTGTTGGAAAAACAGAGCTAGCGAAGCAATTAGCGCTTGATATGTTTGGTACTAAAGAAGCCATTATCCGT
TTGGACATGTCTGAATACTCTGACCGCACAGCTGTGTCGAAATTGATTGGTACAACAGCTGGTTATGTGGGGTATGATGA
CAATAGCAACACGTTGACAGAACGTGTTCGTCGGAATCCTTACTCTATCATCTTGCTGGACGAAATTGAAAAAGCCGATC
CACAAGTCATCACATTGTTACTACAAGTTTTGGACGATGGACGTCTGACAGATGGACAAGGAAATACTGTCAACTTTAAG
AACACAGTTATTATTGCTACATCAAATGCTGGATTTGGGTATGAAAGCTTTACTGGTGATGAGGAAAAGGATAGGAAGAT
TATGGATCGCTTAAAACCATACTTCCGCCCAGAATTCTTGAATCGCTTCAATGCAGTCATTGAATTCTCTCATCTTGGTA
AAGAAGATTTAGCCGAAATCGTCGACTTGATGTTGGATGAGGTCAACCAAACACTTGCTAAGAAAGACATTATGCTAACA
GTAACAGATGCGGCCAAACATTATCTAGCAGAAGAGGGATATGATGAAGTTATGGGTGTTCGTCCGCTTCGTCGTGTGAT
TGAGCAACAAATCCGTGATAAGGTAACAGACTATCATCTTGATCATTTAGATGCGAAACATCTTCTTGCATATTTGAAAG
ATGATGAATTAGTTATCGAAGAAGCGAAAGAGCATCAAACGAAAAAATAA

Domains

Predicted by InterProScan.

• AAA lid domain (AAA_lid_9) (261-356)

• ATPase family associated with various cellular activities (AAA) (AAA) (120-252)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (612-682)

• AAA domain (Cdc48 subfamily) (AAA_2) (445-605)

3D structure

• AlphaFold DB: T1ZGZ9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	46.121	100	0.461
clpC	Lactococcus lactis subsp. cremoris KW2	51.189	88.999	0.456
clpE	Streptococcus pneumoniae R6	44.895	100	0.453
clpE	Streptococcus pneumoniae D39	44.895	100	0.453
clpE	Streptococcus pneumoniae Rx1	44.895	100	0.453
clpE	Streptococcus pneumoniae TIGR4	44.663	100	0.449
clpC	Bacillus subtilis subsp. subtilis str. 168	47.059	91.114	0.429
clpC	Streptococcus pneumoniae Rx1	42.613	90.691	0.386
clpC	Streptococcus pneumoniae D39	42.613	90.691	0.386
clpC	Streptococcus pneumoniae TIGR4	42.457	90.691	0.385
clpC	Streptococcus mutans UA159	43.76	87.024	0.381
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	43.506	86.883	0.378
clpC	Streptococcus thermophilus LMD-9	42.788	87.024	0.372
clpC	Streptococcus thermophilus LMG 18311	42.626	87.024	0.371