Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | BrnTA/RHH-COG2929 |
| Location | 959245..959879 | Replicon | chromosome |
| Accession | NC_007618 | ||
| Organism | Brucella melitensis biovar Abortus 2308 | ||
Toxin (Protein)
| Gene name | brnT | Uniprot ID | A0A7U8PD14 |
| Locus tag | BAB_RS20710 | Protein ID | WP_002966807.1 |
| Coordinates | 959559..959804 (-) | Length | 82 a.a. |
Antitoxin (Protein)
| Gene name | brnA | Uniprot ID | Q57DF1 |
| Locus tag | BAB_RS20705 | Protein ID | WP_002964097.1 |
| Coordinates | 959245..959559 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BAB_RS20650 | 954937..955140 | - | 204 | WP_002964087.1 | hypothetical protein | - |
| BAB_RS20655 | 955143..955358 | - | 216 | WP_002971459.1 | hypothetical protein | - |
| BAB_RS20660 | 955355..955558 | - | 204 | WP_002964088.1 | hypothetical protein | - |
| BAB_RS32510 | 955608..956326 | + | 719 | Protein_918 | hypothetical protein | - |
| BAB_RS20675 (BAB1_0986) | 956323..956553 | + | 231 | WP_002964091.1 | hypothetical protein | - |
| BAB_RS20680 (BAB1_0987) | 956550..956825 | + | 276 | WP_002964092.1 | hypothetical protein | - |
| BAB_RS20685 (BAB1_0988) | 956848..957324 | + | 477 | WP_002966806.1 | hypothetical protein | - |
| BAB_RS32515 | 957670..958379 | + | 710 | Protein_922 | porin family protein | - |
| BAB_RS20700 (BAB1_0991) | 958727..958897 | - | 171 | WP_002964095.1 | DUF1508 domain-containing protein | - |
| BAB_RS20705 (BAB1_0993) | 959245..959559 | - | 315 | WP_002964097.1 | BrnA antitoxin family protein | Antitoxin |
| BAB_RS20710 (BAB1_0994) | 959559..959804 | - | 246 | WP_002966807.1 | BrnT family toxin | Toxin |
| BAB_RS20715 (BAB1_0995) | 959937..960575 | + | 639 | Protein_926 | tRNA-guanine transglycosylase | - |
| BAB_RS33640 | 960645..961402 | + | 758 | WP_102040076.1 | IS5 family transposase | - |
| BAB_RS33645 | 961403..962176 | + | 774 | Protein_928 | hypothetical protein | - |
| BAB_RS20740 (BAB1_0998) | 962505..963956 | + | 1452 | WP_004685623.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | wboA / wbdA | 953925..967272 | 13347 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9162.82 Da Isoelectric Point: 10.3158
>T6121 WP_002966807.1 NC_007618:c959804-959559 [Brucella abortus 2308]
MKIIWDEPKRQTNIAKHGLDFADLHFEFFLSAKVFPTKADRLMAIGEFNGLIIIAVIFKPVGSEALSVISMRSASQKERK
L
MKIIWDEPKRQTNIAKHGLDFADLHFEFFLSAKVFPTKADRLMAIGEFNGLIIIAVIFKPVGSEALSVISMRSASQKERK
L
Download Length: 246 bp
>T6121 NC_007618:c959804-959559 [Brucella abortus 2308]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCTTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCTTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11638.42 Da Isoelectric Point: 10.3131
>AT6121 WP_002964097.1 NC_007618:c959559-959245 [Brucella abortus 2308]
MGIKFSSKRPLTQEEEAEIQKMIASDPDAPEATDEQLAKAKPFKEAFPDMAAKMEKAIRGRPRIDNPKTPVTIRLDQDVV
QRFKATGKGWQGRMNDALRKAVGL
MGIKFSSKRPLTQEEEAEIQKMIASDPDAPEATDEQLAKAKPFKEAFPDMAAKMEKAIRGRPRIDNPKTPVTIRLDQDVV
QRFKATGKGWQGRMNDALRKAVGL
Download Length: 315 bp
>AT6121 NC_007618:c959559-959245 [Brucella abortus 2308]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAAGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATGAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAAGCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAAGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATGAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAAGCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T2224 | Brucella melitensis biovar Abortus 2308 |
100 |
100 |
1 |
| T6082 | Acinetobacter baumannii |
31.325 |
100 |
0.321 |
| T10188 | Acinetobacter baumannii strain ORAB01 |
31.325 |
100 |
0.321 |
| T6081 | Acinetobacter baumannii |
31.325 |
100 |
0.321 |
| T6086 | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
28.736 |
100 |
0.309 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT2224 | Brucella melitensis biovar Abortus 2308 |
100 |
100 |
1 |
| AT1547 | Burkholderia pseudomallei K96243 |
44.444 |
100 |
0.468 |
| AT6082 | Acinetobacter baumannii |
30.357 |
100 |
0.333 |
| AT6081 | Acinetobacter baumannii |
30.357 |
100 |
0.333 |
| AT10188 | Acinetobacter baumannii strain ORAB01 |
30.357 |
100 |
0.327 |
Multiple sequence alignment
References
(1) Brook E Heaton et al. (2012) Molecular structure and function of the novel BrnT/BrnA toxin-antitoxin system of Brucella abortus. The Journal of Biological Chemistry 287(15):12098-110. [PubMed:22334680]