46887

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 509727..510286 Replicon chromosome
Accession NZ_CP007682
Organism Brucella abortus strain BER

Toxin (Protein)


Gene name brnT Uniprot ID A0A7U8PD14
Locus tag DK51_RS02405 Protein ID WP_002966807.1
Coordinates 509727..509972 (+) Length 82 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q57DF1
Locus tag DK51_RS02410 Protein ID WP_002964097.1
Coordinates 509972..510286 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK51_RS02380 505575..507026 - 1452 WP_004685623.1 hypothetical protein -
DK51_RS02385 507355..508128 - 774 WP_002967634.1 hypothetical protein -
DK51_RS02400 508956..509594 - 639 Protein_478 tRNA-guanine transglycosylase -
DK51_RS02405 509727..509972 + 246 WP_002966807.1 BrnT family toxin Toxin
DK51_RS02410 509972..510286 + 315 WP_002964097.1 BrnA antitoxin family protein Antitoxin
DK51_RS02415 510634..510804 + 171 WP_002964095.1 DUF1508 domain-containing protein -
DK51_RS16040 511152..511861 - 710 Protein_482 porin family protein -
DK51_RS02430 512207..512683 - 477 WP_002966806.1 hypothetical protein -
DK51_RS02435 512706..512980 - 275 Protein_484 hypothetical protein -
DK51_RS02440 512977..513207 - 231 WP_002964091.1 hypothetical protein -
DK51_RS02445 513204..513923 - 720 WP_006103139.1 hypothetical protein -
DK51_RS02450 513973..514176 + 204 WP_002964088.1 hypothetical protein -
DK51_RS02455 514173..514388 + 216 WP_002971459.1 hypothetical protein -
DK51_RS02460 514391..514594 + 204 WP_002964087.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - wbdA / wboA 502461..516367 13906


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-78)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-102)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9162.82 Da        Isoelectric Point: 10.3158

>T46887 WP_002966807.1 NZ_CP007682:509727-509972 [Brucella abortus]
MKIIWDEPKRQTNIAKHGLDFADLHFEFFLSAKVFPTKADRLMAIGEFNGLIIIAVIFKPVGSEALSVISMRSASQKERK
L

Download         Length: 246 bp

>T46887 NZ_CP007682:509727-509972 [Brucella abortus]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCTTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11638.42 Da        Isoelectric Point: 10.3131

>AT46887 WP_002964097.1 NZ_CP007682:509972-510286 [Brucella abortus]
MGIKFSSKRPLTQEEEAEIQKMIASDPDAPEATDEQLAKAKPFKEAFPDMAAKMEKAIRGRPRIDNPKTPVTIRLDQDVV
QRFKATGKGWQGRMNDALRKAVGL

Download         Length: 315 bp

>AT46887 NZ_CP007682:509972-510286 [Brucella abortus]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAAGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATGAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAAGCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8PD14

Antitoxin

Source ID Structure

References