207769

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 959345..959904 Replicon chromosome
Accession NZ_CP077765
Organism Brucella abortus strain 19BA

Toxin (Protein)


Gene name brnT Uniprot ID A0A7U8PD14
Locus tag DOL90_RS10195 Protein ID WP_002966807.1
Coordinates 959659..959904 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q57DF1
Locus tag DOL90_RS10190 Protein ID WP_002964097.1
Coordinates 959345..959659 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DOL90_RS10145 (DOL90_010145) 955037..955240 - 204 WP_002964087.1 hypothetical protein -
DOL90_RS10150 (DOL90_010150) 955243..955458 - 216 WP_002971459.1 hypothetical protein -
DOL90_RS10155 (DOL90_010155) 955455..955658 - 204 WP_002964088.1 hypothetical protein -
DOL90_RS10160 (DOL90_010160) 955708..956271 + 564 WP_233274594.1 hypothetical protein -
DOL90_RS10165 (DOL90_010165) 956423..956653 + 231 WP_002964091.1 hypothetical protein -
DOL90_RS10170 (DOL90_010170) 956650..956925 + 276 WP_002964092.1 hypothetical protein -
DOL90_RS10175 (DOL90_010175) 957017..957424 + 408 WP_002971458.1 hypothetical protein -
DOL90_RS10180 (DOL90_010180) 957770..958479 + 710 Protein_933 porin family protein -
DOL90_RS10185 (DOL90_010185) 958827..958997 - 171 WP_002964095.1 DUF1508 domain-containing protein -
DOL90_RS16160 958996..959229 + 234 WP_002969999.1 hypothetical protein -
DOL90_RS10190 (DOL90_010190) 959345..959659 - 315 WP_002964097.1 BrnA antitoxin family protein Antitoxin
DOL90_RS10195 (DOL90_010195) 959659..959904 - 246 WP_002966807.1 BrnT family toxin Toxin
DOL90_RS10200 (DOL90_010200) 960037..960675 + 639 Protein_938 tRNA guanosine transglycosylase -
DOL90_RS10205 (DOL90_010205) 960745..961502 + 758 WP_102040076.1 IS5 family transposase -
DOL90_RS10210 (DOL90_010210) 961503..962276 + 774 Protein_940 hypothetical protein -
DOL90_RS10215 (DOL90_010215) 962605..964056 + 1452 WP_004685623.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - wboA / wbdA 954025..967372 13347


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-78)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-102)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9162.82 Da        Isoelectric Point: 10.3158

>T207769 WP_002966807.1 NZ_CP077765:c959904-959659 [Brucella abortus]
MKIIWDEPKRQTNIAKHGLDFADLHFEFFLSAKVFPTKADRLMAIGEFNGLIIIAVIFKPVGSEALSVISMRSASQKERK
L

Download         Length: 246 bp

>T207769 NZ_CP103508:2711692-2711799 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCAGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11638.42 Da        Isoelectric Point: 10.3131

>AT207769 WP_002964097.1 NZ_CP077765:c959659-959345 [Brucella abortus]
MGIKFSSKRPLTQEEEAEIQKMIASDPDAPEATDEQLAKAKPFKEAFPDMAAKMEKAIRGRPRIDNPKTPVTIRLDQDVV
QRFKATGKGWQGRMNDALRKAVGL

Download         Length: 315 bp

>AT207769 NZ_CP103508:c2711635-2711580 [Escherichia coli O25b:H4-ST131]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8PD14

Antitoxin

Source ID Structure

References