22899

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 960424..960983 Replicon chromosome
Accession NC_010742
Organism Brucella abortus S19

Toxin (Protein)


Gene name brnT Uniprot ID A0A7U8PD14
Locus tag BABS19_RS04780 Protein ID WP_002966807.1
Coordinates 960738..960983 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q57DF1
Locus tag BABS19_RS04775 Protein ID WP_002964097.1
Coordinates 960424..960738 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BABS19_RS04720 956116..956319 - 204 WP_002964087.1 hypothetical protein -
BABS19_RS04725 956322..956537 - 216 WP_002971459.1 hypothetical protein -
BABS19_RS04730 956534..956737 - 204 WP_002964088.1 hypothetical protein -
BABS19_RS16665 956787..957505 + 719 Protein_919 hypothetical protein -
BABS19_RS04745 957502..957732 + 231 WP_002964091.1 hypothetical protein -
BABS19_RS04750 957729..958004 + 276 WP_002964092.1 hypothetical protein -
BABS19_RS04755 958027..958503 + 477 WP_002966806.1 hypothetical protein -
BABS19_RS16670 958849..959558 + 710 Protein_923 porin family protein -
BABS19_RS04770 959906..960076 - 171 WP_002964095.1 DUF1508 domain-containing protein -
BABS19_RS04775 960424..960738 - 315 WP_002964097.1 BrnA antitoxin family protein Antitoxin
BABS19_RS04780 960738..960983 - 246 WP_002966807.1 BrnT family toxin Toxin
BABS19_RS04785 961116..961754 + 639 Protein_927 tRNA-guanine transglycosylase -
BABS19_RS17810 961824..962581 + 758 WP_102040076.1 IS5 family transposase -
BABS19_RS17815 962582..963355 + 774 Protein_929 hypothetical protein -
BABS19_RS04810 963684..965135 + 1452 WP_004685623.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - wboA / wbdA 955104..968451 13347


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-78)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-102)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9162.82 Da        Isoelectric Point: 10.3158

>T22899 WP_002966807.1 NC_010742:c960983-960738 [Brucella abortus S19]
MKIIWDEPKRQTNIAKHGLDFADLHFEFFLSAKVFPTKADRLMAIGEFNGLIIIAVIFKPVGSEALSVISMRSASQKERK
L

Download         Length: 246 bp

>T22899 NC_010742:c960983-960738 [Brucella abortus S19]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCTTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11638.42 Da        Isoelectric Point: 10.3131

>AT22899 WP_002964097.1 NC_010742:c960738-960424 [Brucella abortus S19]
MGIKFSSKRPLTQEEEAEIQKMIASDPDAPEATDEQLAKAKPFKEAFPDMAAKMEKAIRGRPRIDNPKTPVTIRLDQDVV
QRFKATGKGWQGRMNDALRKAVGL

Download         Length: 315 bp

>AT22899 NC_010742:c960738-960424 [Brucella abortus S19]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAAGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATGAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAAGCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8PD14

Antitoxin

Source ID Structure

References