Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | shpAB/RHH-COG2929 |
| Location | 4785649..4786225 | Replicon | chromosome |
| Accession | NC_003197 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 | ||
Toxin (Protein)
| Gene name | shpA | Uniprot ID | - |
| Locus tag | STM4528 | Protein ID | NP_463387.1 |
| Coordinates | 4785667..4785954 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | shpB | Uniprot ID | - |
| Locus tag | STM4529 | Protein ID | NP_463388.1 |
| Coordinates | 4785941..4786243 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| STM4526 | 4780777..4784286 | - | 3510 | NP_463385.1 | endonuclease R | - |
| STM4527 | 4784484..4785398 | + | 915 | NP_463386.1 | restriction of methylated adenine | - |
| STM4528 | 4785667..4785954 | + | 288 | NP_463387.1 | putative inner membrane protein | Toxin |
| STM4529 | 4785941..4786243 | + | 303 | NP_463388.1 | putative cytoplasmic protein | Antitoxin |
| STM4530 | 4786318..4787274 | - | 957 | NP_463389.1 | putative cobalamin synthesis protein | - |
| STM4531 | 4787285..4787488 | - | 204 | NP_463390.1 | putative cytoplasmic protein | - |
| STM4532 | 4787583..4789733 | - | 2151 | NP_463391.1 | putative carbon starvation protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11294.80 Da Isoelectric Point: 9.5894
>T6086 NP_463387.1 NC_003197:4785667-4785954 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG
Download Length: 288 bp
>T6086 NC_003197:4785667-4785954 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11373.96 Da Isoelectric Point: 10.1293
>AT6086 NP_463388.1 NC_003197:4785941-4786243 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK
Download Length: 303 bp
>AT6086 NC_003197:4785941-4786243 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T6081 | Acinetobacter baumannii |
52.632 |
100 |
0.526 |
| T10188 | Acinetobacter baumannii strain ORAB01 |
52.632 |
100 |
0.526 |
| T6082 | Acinetobacter baumannii |
52.632 |
100 |
0.526 |
| T167 | Vibrio cholerae O1 biovar El Tor str. N16961 |
32.292 |
100 |
0.352 |
| T6121 | Brucella melitensis biovar Abortus 2308 |
28.736 |
100 |
0.309 |
| T2224 | Brucella melitensis biovar Abortus 2308 |
28.736 |
100 |
0.309 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT10188 | Acinetobacter baumannii strain ORAB01 |
50.98 |
100 |
0.52 |
| AT6081 | Acinetobacter baumannii |
48.485 |
99 |
0.48 |
| AT6082 | Acinetobacter baumannii |
48.485 |
99 |
0.48 |
Multiple sequence alignment
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Andrew Slattery et al. (2013) Isolation of highly persistent mutants of Salmonella enterica serovar typhimurium reveals a new toxin-antitoxin module. Journal of Bacteriology 195(4):647-57. [PubMed:23204462]