140726

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 955655..956214 Replicon chromosome
Accession NZ_CP044338
Organism Brucella abortus strain clpP

Toxin (Protein)


Gene name brnT Uniprot ID A0A7U8PD14
Locus tag F6Y31_RS05060 Protein ID WP_002966807.1
Coordinates 955969..956214 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q57DF1
Locus tag F6Y31_RS05055 Protein ID WP_002964097.1
Coordinates 955655..955969 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y31_RS05005 951347..951550 - 204 WP_002964087.1 hypothetical protein -
F6Y31_RS05010 951553..951768 - 216 WP_002971459.1 hypothetical protein -
F6Y31_RS05015 951765..951968 - 204 WP_002964088.1 hypothetical protein -
F6Y31_RS05020 952018..952736 + 719 Protein_917 hypothetical protein -
F6Y31_RS05025 952733..952963 + 231 WP_002964091.1 hypothetical protein -
F6Y31_RS05030 952960..953235 + 276 WP_002964092.1 hypothetical protein -
F6Y31_RS05035 953258..953734 + 477 WP_002966806.1 hypothetical protein -
F6Y31_RS05040 954080..954789 + 710 Protein_921 porin family protein -
F6Y31_RS05045 955137..955307 - 171 WP_002964095.1 DUF1508 domain-containing protein -
F6Y31_RS05055 955655..955969 - 315 WP_002964097.1 BrnA antitoxin family protein Antitoxin
F6Y31_RS05060 955969..956214 - 246 WP_002966807.1 BrnT family toxin Toxin
F6Y31_RS05065 956347..956985 + 639 Protein_925 tRNA-guanine transglycosylase -
F6Y31_RS05070 957055..957812 + 758 WP_102040076.1 IS5 family transposase -
F6Y31_RS05075 957813..958586 + 774 Protein_927 hypothetical protein -
F6Y31_RS05080 958915..960366 + 1452 WP_004685623.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - wboA / wbdA 950335..963682 13347


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-78)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-102)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9162.82 Da        Isoelectric Point: 10.3158

>T140726 WP_002966807.1 NZ_CP044338:c956214-955969 [Brucella abortus]
MKIIWDEPKRQTNIAKHGLDFADLHFEFFLSAKVFPTKADRLMAIGEFNGLIIIAVIFKPVGSEALSVISMRSASQKERK
L

Download         Length: 246 bp

>T140726 NZ_CP059386:c3296752-3296471 [Acinetobacter baumannii]
ATGGCTATCAAACTTCGTAAATGGGATAGTGCTGAGCATCTTAAAACAGAAGAAGATATGCAAGCTTACCTACAAGCCTG
TATCGATGAATCTAATGGTGATGCTGCATTCATTGCTAAAGCTTTAGGTAACATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGTCTAGGCCGAGAAAGTCTTTACAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11638.42 Da        Isoelectric Point: 10.3131

>AT140726 WP_002964097.1 NZ_CP044338:c955969-955655 [Brucella abortus]
MGIKFSSKRPLTQEEEAEIQKMIASDPDAPEATDEQLAKAKPFKEAFPDMAAKMEKAIRGRPRIDNPKTPVTIRLDQDVV
QRFKATGKGWQGRMNDALRKAVGL

Download         Length: 315 bp

>AT140726 NZ_CP059386:c3297055-3296753 [Acinetobacter baumannii]
ATGTACTCAATATATACCACAGAAGCCTTTGATGATTGGTTTACCAAGTTAAAAGATCAACAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGGAACTTTGGAGATACTGAACCAGTCGGTGAAGGTGTTTCTGAGTTACGTTTCT
TCTTTGGACCTGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTCGTTATTCTCTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTACAATTAGCACAAGATTTAGAGGAGGAGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8PD14

Antitoxin

Source ID Structure

References