46911

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 931525..932084 Replicon chromosome
Accession NZ_CP007709
Organism Brucella abortus bv. 6 str. 870

Toxin (Protein)


Gene name brnT Uniprot ID D7H3C9
Locus tag DO74_RS04480 Protein ID WP_002964098.1
Coordinates 931525..931770 (+) Length 82 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q57DF1
Locus tag DO74_RS04485 Protein ID WP_002964097.1
Coordinates 931770..932084 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DO74_RS17855 927568..928917 - 1350 WP_002964100.1 hypothetical protein -
DO74_RS04460 929153..929926 - 774 WP_002967634.1 hypothetical protein -
DO74_RS04475 930754..931392 - 639 Protein_875 tRNA-guanine transglycosylase -
DO74_RS04480 931525..931770 + 246 WP_002964098.1 BrnT family toxin Toxin
DO74_RS04485 931770..932084 + 315 WP_002964097.1 BrnA antitoxin family protein Antitoxin
DO74_RS04490 932432..932602 + 171 WP_002964095.1 DUF1508 domain-containing protein -
DO74_RS16300 932950..933659 - 710 Protein_879 porin family protein -
DO74_RS04505 934005..934481 - 477 WP_002966806.1 hypothetical protein -
DO74_RS04510 934504..934779 - 276 WP_002964092.1 hypothetical protein -
DO74_RS04515 934776..935006 - 231 WP_002964091.1 hypothetical protein -
DO74_RS17910 935003..935313 - 311 Protein_883 hypothetical protein -
DO74_RS04525 935770..935973 + 204 WP_002964088.1 hypothetical protein -
DO74_RS04530 935970..936185 + 216 WP_002971459.1 hypothetical protein -
DO74_RS04535 936188..936391 + 204 WP_002964087.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - wbdA / wboA 924259..938163 13904


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-78)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-102)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9196.83 Da        Isoelectric Point: 10.3158

>T46911 WP_002964098.1 NZ_CP007709:931525-931770 [Brucella abortus bv. 6 str. 870]
MKIFWDEPKRQTNIAKHGLDFADLHFEFFLSAKVFPTKADRLMAIGEFNGLIIIAVIFKPVGSEALSVISMRSASQKERK
L

Download         Length: 246 bp

>T46911 NZ_CP007709:931525-931770 [Brucella abortus bv. 6 str. 870]
ATGAAGATCTTCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCTTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11638.42 Da        Isoelectric Point: 10.3131

>AT46911 WP_002964097.1 NZ_CP007709:931770-932084 [Brucella abortus bv. 6 str. 870]
MGIKFSSKRPLTQEEEAEIQKMIASDPDAPEATDEQLAKAKPFKEAFPDMAAKMEKAIRGRPRIDNPKTPVTIRLDQDVV
QRFKATGKGWQGRMNDALRKAVGL

Download         Length: 315 bp

>AT46911 NZ_CP007709:931770-932084 [Brucella abortus bv. 6 str. 870]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAAGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATGAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAAGCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D7H3C9

Antitoxin

Source ID Structure

References