25866

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 1455443..1456002 Replicon chromosome
Accession NC_016795
Organism Brucella abortus A13334

Toxin (Protein)


Gene name brnT Uniprot ID A0A7U8PD14
Locus tag BAA13334_RS07055 Protein ID WP_002966807.1
Coordinates 1455443..1455688 (+) Length 82 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q57DF1
Locus tag BAA13334_RS07060 Protein ID WP_002964097.1
Coordinates 1455688..1456002 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAA13334_RS07025 1451291..1452742 - 1452 WP_004685623.1 hypothetical protein -
BAA13334_RS17780 1453071..1453844 - 774 Protein_1373 hypothetical protein -
BAA13334_RS07050 1454672..1455310 - 639 Protein_1375 tRNA-guanine transglycosylase -
BAA13334_RS07055 1455443..1455688 + 246 WP_002966807.1 BrnT family toxin Toxin
BAA13334_RS07060 1455688..1456002 + 315 WP_002964097.1 BrnA antitoxin family protein Antitoxin
BAA13334_RS07065 1456350..1456520 + 171 WP_002964095.1 DUF1508 domain-containing protein -
BAA13334_RS16740 1456868..1457577 - 710 Protein_1379 porin family protein -
BAA13334_RS07080 1457923..1458399 - 477 WP_002966806.1 hypothetical protein -
BAA13334_RS07085 1458422..1458697 - 276 WP_002964092.1 hypothetical protein -
BAA13334_RS07090 1458694..1458924 - 231 WP_014315761.1 hypothetical protein -
BAA13334_RS16745 1458921..1459639 - 719 Protein_1383 hypothetical protein -
BAA13334_RS07105 1459689..1459892 + 204 WP_002964088.1 hypothetical protein -
BAA13334_RS07110 1459889..1460104 + 216 WP_002971459.1 hypothetical protein -
BAA13334_RS07115 1460107..1460310 + 204 WP_002964087.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - wbdA / wboA 1448177..1462082 13905


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-78)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-102)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9162.82 Da        Isoelectric Point: 10.3158

>T25866 WP_002966807.1 NC_016795:1455443-1455688 [Brucella abortus A13334]
MKIIWDEPKRQTNIAKHGLDFADLHFEFFLSAKVFPTKADRLMAIGEFNGLIIIAVIFKPVGSEALSVISMRSASQKERK
L

Download         Length: 246 bp

>T25866 NC_016795:1455443-1455688 [Brucella abortus A13334]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCTTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11638.42 Da        Isoelectric Point: 10.3131

>AT25866 WP_002964097.1 NC_016795:1455688-1456002 [Brucella abortus A13334]
MGIKFSSKRPLTQEEEAEIQKMIASDPDAPEATDEQLAKAKPFKEAFPDMAAKMEKAIRGRPRIDNPKTPVTIRLDQDVV
QRFKATGKGWQGRMNDALRKAVGL

Download         Length: 315 bp

>AT25866 NC_016795:1455688-1456002 [Brucella abortus A13334]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAAGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATGAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAAGCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8PD14

Antitoxin

Source ID Structure

References