46909

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 881081..881640 Replicon chromosome
Accession NZ_CP007700
Organism Brucella abortus strain NCTC 10505

Toxin (Protein)


Gene name brnT Uniprot ID D7H3C9
Locus tag DO78_RS05725 Protein ID WP_002964098.1
Coordinates 881395..881640 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q57DF1
Locus tag DO78_RS05730 Protein ID WP_002964097.1
Coordinates 881081..881395 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DO78_RS05770 876774..876977 - 204 WP_002964087.1 hypothetical protein -
DO78_RS05765 876980..877195 - 216 WP_002971459.1 hypothetical protein -
DO78_RS05760 877192..877395 - 204 WP_002964088.1 hypothetical protein -
DO78_RS18210 877852..878162 + 311 Protein_853 hypothetical protein -
DO78_RS05755 878159..878389 + 231 WP_002964091.1 hypothetical protein -
DO78_RS05750 878386..878661 + 276 WP_002964092.1 hypothetical protein -
DO78_RS15335 878684..879160 + 477 WP_002966806.1 hypothetical protein -
DO78_RS16595 879506..880215 + 710 Protein_857 porin family protein -
DO78_RS05735 880563..880733 - 171 WP_002964095.1 DUF1508 domain-containing protein -
DO78_RS18320 880732..880965 + 234 WP_002969999.1 hypothetical protein -
DO78_RS05730 881081..881395 - 315 WP_002964097.1 BrnA antitoxin family protein Antitoxin
DO78_RS05725 881395..881640 - 246 WP_002964098.1 BrnT family toxin Toxin
DO78_RS15880 881773..882411 + 639 Protein_862 tRNA-guanine transglycosylase -
DO78_RS17810 882481..883238 + 758 WP_094866390.1 IS5 family transposase -
DO78_RS05705 883239..884012 + 774 WP_002967634.1 hypothetical protein -
DO78_RS15885 884341..885792 + 1452 Protein_865 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - wboA / wbdA 875002..889108 14106


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-78)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-102)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9196.83 Da        Isoelectric Point: 10.3158

>T46909 WP_002964098.1 NZ_CP007700:c881640-881395 [Brucella abortus]
MKIFWDEPKRQTNIAKHGLDFADLHFEFFLSAKVFPTKADRLMAIGEFNGLIIIAVIFKPVGSEALSVISMRSASQKERK
L

Download         Length: 246 bp

>T46909 NZ_CP007700:c881640-881395 [Brucella abortus]
ATGAAGATCTTCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCTTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11638.42 Da        Isoelectric Point: 10.3131

>AT46909 WP_002964097.1 NZ_CP007700:c881395-881081 [Brucella abortus]
MGIKFSSKRPLTQEEEAEIQKMIASDPDAPEATDEQLAKAKPFKEAFPDMAAKMEKAIRGRPRIDNPKTPVTIRLDQDVV
QRFKATGKGWQGRMNDALRKAVGL

Download         Length: 315 bp

>AT46909 NZ_CP007700:c881395-881081 [Brucella abortus]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAAGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATGAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAAGCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D7H3C9

Antitoxin

Source ID Structure

References