46910

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 974478..975037 Replicon chromosome
Accession NZ_CP007705
Organism Brucella abortus bv. 9 str. C68

Toxin (Protein)


Gene name brnT Uniprot ID D7H3C9
Locus tag DK53_RS04825 Protein ID WP_002964098.1
Coordinates 974792..975037 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q57DF1
Locus tag DK53_RS04820 Protein ID WP_002964097.1
Coordinates 974478..974792 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK53_RS04765 970171..970374 - 204 WP_002964087.1 hypothetical protein -
DK53_RS04770 970377..970592 - 216 WP_002971459.1 hypothetical protein -
DK53_RS04775 970589..970792 - 204 WP_002964088.1 hypothetical protein -
DK53_RS17945 971249..971559 + 311 Protein_935 hypothetical protein -
DK53_RS04790 971556..971786 + 231 WP_002964091.1 hypothetical protein -
DK53_RS04795 971783..972058 + 276 WP_002964092.1 hypothetical protein -
DK53_RS04800 972081..972557 + 477 WP_002966806.1 hypothetical protein -
DK53_RS16410 972903..973612 + 710 Protein_939 porin family protein -
DK53_RS04815 973960..974130 - 171 WP_002964095.1 DUF1508 domain-containing protein -
DK53_RS04820 974478..974792 - 315 WP_002964097.1 BrnA antitoxin family protein Antitoxin
DK53_RS04825 974792..975037 - 246 WP_002964098.1 BrnT family toxin Toxin
DK53_RS04830 975170..975808 + 639 Protein_943 tRNA-guanine transglycosylase -
DK53_RS17595 975878..976634 + 757 Protein_944 IS5 family transposase -
DK53_RS04840 976635..977408 + 774 WP_002967634.1 hypothetical protein -
DK53_RS04845 977737..979188 + 1452 WP_032449309.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - wboA / wbdA 968399..982504 14105
- flank IS/Tn - - 975878..976246 368


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-78)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-102)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9196.83 Da        Isoelectric Point: 10.3158

>T46910 WP_002964098.1 NZ_CP007705:c975037-974792 [Brucella abortus bv. 9 str. C68]
MKIFWDEPKRQTNIAKHGLDFADLHFEFFLSAKVFPTKADRLMAIGEFNGLIIIAVIFKPVGSEALSVISMRSASQKERK
L

Download         Length: 246 bp

>T46910 NZ_CP007705:c975037-974792 [Brucella abortus bv. 9 str. C68]
ATGAAGATCTTCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCTTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11638.42 Da        Isoelectric Point: 10.3131

>AT46910 WP_002964097.1 NZ_CP007705:c974792-974478 [Brucella abortus bv. 9 str. C68]
MGIKFSSKRPLTQEEEAEIQKMIASDPDAPEATDEQLAKAKPFKEAFPDMAAKMEKAIRGRPRIDNPKTPVTIRLDQDVV
QRFKATGKGWQGRMNDALRKAVGL

Download         Length: 315 bp

>AT46910 NZ_CP007705:c974792-974478 [Brucella abortus bv. 9 str. C68]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAAGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATGAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAAGCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D7H3C9

Antitoxin

Source ID Structure

References