46999

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 981835..982394 Replicon chromosome
Accession NZ_CP007765
Organism Brucella abortus bv.

Toxin (Protein)


Gene name brnT Uniprot ID A0A7U8PD14
Locus tag DK55_RS10405 Protein ID WP_002966807.1
Coordinates 982149..982394 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q57DF1
Locus tag DK55_RS10400 Protein ID WP_002964097.1
Coordinates 981835..982149 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK55_RS10345 977527..977730 - 204 WP_002964087.1 hypothetical protein -
DK55_RS10350 977733..977948 - 216 WP_002971459.1 hypothetical protein -
DK55_RS10355 977945..978148 - 204 WP_002964088.1 hypothetical protein -
DK55_RS17100 978198..978916 + 719 Protein_939 hypothetical protein -
DK55_RS10370 978913..979143 + 231 WP_002964091.1 hypothetical protein -
DK55_RS10375 979140..979415 + 276 WP_002964092.1 hypothetical protein -
DK55_RS10380 979438..979914 + 477 WP_002966806.1 hypothetical protein -
DK55_RS17105 980260..980969 + 710 Protein_943 porin family protein -
DK55_RS10395 981317..981487 - 171 WP_002964095.1 DUF1508 domain-containing protein -
DK55_RS10400 981835..982149 - 315 WP_002964097.1 BrnA antitoxin family protein Antitoxin
DK55_RS10405 982149..982394 - 246 WP_002966807.1 BrnT family toxin Toxin
DK55_RS10410 982527..983165 + 639 Protein_947 tRNA-guanine transglycosylase -
DK55_RS17805 983235..983992 + 758 WP_102040428.1 IS5 family transposase -
DK55_RS17810 983993..984766 + 774 Protein_949 hypothetical protein -
DK55_RS10435 985095..986546 + 1452 WP_004685623.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - wboA / wbdA 976515..989862 13347


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-78)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-102)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9162.82 Da        Isoelectric Point: 10.3158

>T46999 WP_002966807.1 NZ_CP007765:c982394-982149 [Brucella abortus bv. 2 str. 86/8/59]
MKIIWDEPKRQTNIAKHGLDFADLHFEFFLSAKVFPTKADRLMAIGEFNGLIIIAVIFKPVGSEALSVISMRSASQKERK
L

Download         Length: 246 bp

>T46999 NZ_CP007765:c982394-982149 [Brucella abortus bv. 2 str. 86/8/59]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCTTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11638.42 Da        Isoelectric Point: 10.3131

>AT46999 WP_002964097.1 NZ_CP007765:c982149-981835 [Brucella abortus bv. 2 str. 86/8/59]
MGIKFSSKRPLTQEEEAEIQKMIASDPDAPEATDEQLAKAKPFKEAFPDMAAKMEKAIRGRPRIDNPKTPVTIRLDQDVV
QRFKATGKGWQGRMNDALRKAVGL

Download         Length: 315 bp

>AT46999 NZ_CP007765:c982149-981835 [Brucella abortus bv. 2 str. 86/8/59]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAAGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATGAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAAGCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8PD14

Antitoxin

Source ID Structure

References