Detailed information NTG0845222

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: V2195_RS26745
• Genome accession: NZ_CP143903
• Coordinates: 5587624..5588295 (+)
• Length: 223 a.a.
• NCBI ID: WP_003090494.1
• Uniprot ID: A0A0H2ZC88
• Organism: Pseudomonas aeruginosa strain PA13_L17_27.22_ST207
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 5582624..5593295

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
V2195_RS26710 (V2195_26710)	ppyR	5583097..5583354 (+)	258	WP_003090502.1	psl/pyoverdine operon transcriptional regulator PpyR	-
V2195_RS26715 (V2195_26715)	-	5583341..5584534 (+)	1194	WP_003131074.1	NnrS family protein	-
V2195_RS26720 (V2195_26720)	-	5584535..5584801 (-)	267	WP_003090500.1	DUF5329 domain-containing protein	-
V2195_RS26725 (V2195_26725)	-	5584785..5585678 (-)	894	WP_003110080.1	hypothetical protein	-
V2195_RS26730 (V2195_26730)	-	5585705..5586787 (-)	1083	WP_003113385.1	hypothetical protein	-
V2195_RS26735 (V2195_26735)	-	5587002..5587310 (+)	309	WP_003090497.1	PepSY domain-containing protein	-
V2195_RS26740 (V2195_26740)	-	5587310..5587624 (+)	315	WP_003097704.1	PepSY domain-containing protein	-
V2195_RS26745 (V2195_26745)	ciaR	5587624..5588295 (+)	672	WP_003090494.1	two-component system response regulator CarR	Regulator
V2195_RS26750 (V2195_26750)	carS	5588292..5589629 (+)	1338	WP_003097701.1	two-component system sensor histidine kinase CarS	-
V2195_RS26755 (V2195_26755)	-	5589720..5590028 (+)	309	WP_003097699.1	hypothetical protein	-
V2195_RS30145	-	5590033..5590569 (-)	537	Protein_5280	methyl-accepting chemotaxis protein	-
V2195_RS30150	-	5590891..5592177 (-)	1287	Protein_5281	HAMP domain-containing protein	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 24729.20 Da
• Isoelectric Point: 5.8445

>NTDB_id=845222 V2195_RS26745 WP_003090494.1 5587624..5588295(+) (ciaR) [Pseudomonas aeruginosa strain PA13_L17_27.22_ST207]
MRLLLVEDHVPLADELMASLTRQGYAVDWLADGRDAAVQGASEPYDLIILDLGLPGRPGLEILQEWRGLGLATPVLILTA
RGSWAERIDGLKAGADDYLTKPFHPEELALRIQALLRRAHGLANQSQLEAAGLRLDEQRQCVCLNGADVDLTAAEFRLLR
YFMLHPGQVLSKGHLAEHLYDGETERDSNVIEVHVNHLRRKLGREVIETRRGQGYRYAGVAAG

Nucleotide

• Length: 672 bp

>NTDB_id=845222 V2195_RS26745 WP_003090494.1 5587624..5588295(+) (ciaR) [Pseudomonas aeruginosa strain PA13_L17_27.22_ST207]
ATGCGGTTGCTGCTGGTTGAGGATCACGTTCCCCTGGCCGACGAACTGATGGCCAGCCTGACCCGCCAGGGCTACGCGGT
GGACTGGCTGGCCGACGGCCGCGACGCGGCGGTGCAGGGCGCCAGCGAGCCCTACGACCTGATCATCCTCGACCTCGGCC
TGCCCGGGCGCCCCGGCCTGGAGATACTCCAGGAGTGGCGTGGCCTGGGACTCGCGACTCCGGTGCTGATCCTCACCGCG
CGCGGTTCCTGGGCCGAACGCATCGATGGGCTCAAGGCCGGTGCCGACGACTACCTGACCAAGCCGTTCCATCCGGAAGA
GTTGGCCTTGCGCATCCAGGCCCTGTTGCGCCGCGCCCATGGGCTGGCCAACCAGAGCCAGCTGGAGGCCGCCGGGCTGC
GCCTGGACGAGCAGCGCCAGTGCGTGTGCCTGAACGGCGCCGACGTCGACCTGACCGCCGCCGAATTCCGCCTGCTGCGC
TATTTCATGCTGCACCCCGGCCAGGTCCTGTCCAAGGGGCACCTGGCCGAGCATCTGTACGACGGCGAGACCGAACGCGA
TTCCAACGTCATCGAGGTCCACGTCAACCACCTGCGGCGCAAGCTCGGCCGCGAGGTGATCGAGACCCGCCGTGGCCAGG
GCTACCGCTACGCCGGGGTGGCCGCCGGATGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (147-216)

3D structure

• AlphaFold DB: A0A0H2ZC88

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	37.727	98.655	0.372
ciaR	Streptococcus pneumoniae Rx1	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae D39	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae R6	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae TIGR4	37.273	98.655	0.368
micA	Streptococcus pneumoniae Cp1015	35.683	100	0.363
vicR	Streptococcus mutans UA159	35.526	100	0.363