Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGD   Type   Machinery gene
Locus tag   STU_RS18135 Genome accession   NC_006448
Coordinates   1656856..1657284 (-) Length   142 a.a.
NCBI ID   WP_011226626.1    Uniprot ID   -
Organism   Streptococcus thermophilus LMG 18311     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1651856..1662284
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  STU_RS18095 (stu1854) - 1651989..1652437 (-) 449 Protein_1626 CAAX protease -
  STU_RS20820 (stu1855) - 1652511..1652936 (-) 426 WP_041827107.1 CPBP family intramembrane glutamic endopeptidase -
  STU_RS18105 (stu1856) - 1653179..1653376 (-) 198 WP_011681682.1 helix-turn-helix transcriptional regulator -
  STU_RS18110 (stu1857) - 1653625..1654818 (-) 1194 WP_022096898.1 acetate kinase -
  STU_RS18115 (stu1858) comYH 1654874..1655830 (-) 957 WP_011226622.1 class I SAM-dependent methyltransferase Machinery gene
  STU_RS18120 (stu1859) comGG 1655875..1656192 (-) 318 WP_011226623.1 competence type IV pilus minor pilin ComGG Machinery gene
  STU_RS18125 (stu1860) comGF 1656170..1656607 (-) 438 WP_014608742.1 competence type IV pilus minor pilin ComGF Machinery gene
  STU_RS18130 (stu1861) comGE 1656591..1656884 (-) 294 WP_011226625.1 competence type IV pilus minor pilin ComGE Machinery gene
  STU_RS18135 (stu1862) comGD 1656856..1657284 (-) 429 WP_011226626.1 competence type IV pilus minor pilin ComGD Machinery gene
  STU_RS18140 (stu1863) comGC 1657244..1657570 (-) 327 WP_011226627.1 competence type IV pilus major pilin ComGC Machinery gene
  STU_RS18145 (stu1864) comGB 1657567..1658667 (-) 1101 WP_148148900.1 competence type IV pilus assembly protein ComGB Machinery gene
  STU_RS18150 (stu1865) comGA 1658549..1659490 (-) 942 WP_011226629.1 competence type IV pilus ATPase ComGA Machinery gene
  STU_RS18155 (stu1866) - 1659571..1659933 (-) 363 WP_011226630.1 DUF1033 family protein -

Regulatory network

Positive effect      
Negative effect
Regulator Target Regulation
  comX comGD positive effect
  comX ssbA positive effect
  comX comGE positive effect
  comX comGB positive effect
  comX comGF positive effect
  comX comGG positive effect
  comX radA positive effect
  comX comEC positive effect
  comX comFC positive effect
  comX recA positive effect
  comX comEA positive effect
  comX comGC positive effect
  comX cinA positive effect
  comX coiA positive effect
  comX comGA positive effect
  comX comFA positive effect
  comX dprA positive effect
  clpC comX negative effect
  comR comX positive effect
  comR comS positive effect
  comS comX positive effect
  comS comS positive effect
  amiC comS positive effect
  eeP comS positive effect
  amiD comS positive effect
  amiF comS positive effect
  amiA3 comS positive effect
  amiE comS positive effect
  clpP comX negative effect
  mecA comX negative effect

Sequence

Protein


Download         Length: 142 a.a.        Molecular weight: 15859.45 Da        Isoelectric Point: 10.3330

>NTDB_id=339 STU_RS18135 WP_011226626.1 1656856..1657284(-) (comGD) [Streptococcus thermophilus LMG 18311]
MRNMVVKAAQWPIRAFTLLESLMTLAVVVFLTLSLSGSVTGIFQQVEINLFYLRFEYLYRDSQRLASAEGSNVELQLTKD
KVSNGRSSLLIPKSIHLDKGQTLVFDAKGGNSSLTKIRFSSDKEVVTYLLNMGSGKYKKTIS

Nucleotide


Download         Length: 429 bp        

>NTDB_id=339 STU_RS18135 WP_011226626.1 1656856..1657284(-) (comGD) [Streptococcus thermophilus LMG 18311]
ATGCGAAACATGGTGGTGAAAGCCGCTCAGTGGCCAATTAGAGCTTTCACCTTGTTGGAGAGCCTGATGACACTAGCAGT
GGTTGTCTTTCTCACTCTGAGTTTGTCAGGCTCAGTCACAGGTATTTTTCAGCAGGTCGAGATTAATCTTTTTTATCTGC
GTTTTGAGTACCTATATCGAGATAGTCAGCGCTTGGCATCAGCGGAAGGATCTAATGTTGAATTGCAGTTAACTAAGGAT
AAGGTTAGTAATGGAAGGTCTAGTCTGCTTATTCCTAAAAGTATTCATCTGGATAAGGGGCAGACGCTAGTGTTTGATGC
TAAAGGAGGCAACTCTAGCCTCACGAAAATTCGTTTTTCAAGTGATAAGGAGGTGGTGACCTATCTGCTTAACATGGGCA
GTGGTAAATATAAAAAGACGATCTCTTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYD Streptococcus mutans UA140

52.672

92.254

0.486
  comYD Streptococcus mutans UA159

52.672

92.254

0.486
  comYD Streptococcus gordonii str. Challis substr. CH1

41.429

98.592

0.408
  comGD/cglD Streptococcus pneumoniae Rx1

44.094

89.437

0.394
  comGD/cglD Streptococcus pneumoniae D39

44.094

89.437

0.394
  comGD/cglD Streptococcus pneumoniae R6

44.094

89.437

0.394
  comGD/cglD Streptococcus mitis NCTC 12261

44.094

89.437

0.394
  comGD/cglD Streptococcus pneumoniae TIGR4

44.094

89.437

0.394
  comGD/cglD Streptococcus mitis SK321

43.307

89.437

0.387
  comGD Lactococcus lactis subsp. cremoris KW2

40.909

92.958

0.38

Multiple sequence alignment