Detailed information NTG1016752

Bioinformatically predicted

Overview

• Name: pknB
• Type: Regulator
• Locus tag: DQM44_RS08000
• Genome accession: NZ_LS483318
• Coordinates: 1576463..1578358 (-)
• Length: 631 a.a.
• NCBI ID: WP_022555036.1
• Uniprot ID: -
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC5370
• Function: modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology) Competence regulation

Genomic Context

Location: 1571463..1583358

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM44_RS07975 (NCTC5370_01640)	-	1572213..1572572 (-)	360	WP_003056775.1	S1 RNA-binding domain-containing protein	-
DQM44_RS07980 (NCTC5370_01641)	-	1572572..1573972 (-)	1401	WP_022555032.1	bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase	-
DQM44_RS07985 (NCTC5370_01642)	vraR	1574009..1574650 (-)	642	WP_014612503.1	response regulator transcription factor	Regulator
DQM44_RS07990 (NCTC5370_01643)	-	1574643..1575647 (-)	1005	WP_003061197.1	sensor histidine kinase	-
DQM44_RS07995 (NCTC5370_01644)	liaF	1575644..1576336 (-)	693	WP_065355122.1	cell wall-active antibiotics response protein LiaF	-
DQM44_RS08000 (NCTC5370_01645)	pknB	1576463..1578358 (-)	1896	WP_022555036.1	Stk1 family PASTA domain-containing Ser/Thr kinase	Regulator
DQM44_RS08005 (NCTC5370_01646)	-	1578355..1579095 (-)	741	WP_014612505.1	Stp1/IreP family PP2C-type Ser/Thr phosphatase	-
DQM44_RS08010 (NCTC5370_01647)	rsmB	1579133..1580455 (-)	1323	WP_044565636.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
DQM44_RS08015 (NCTC5370_01648)	fmt	1580445..1581380 (-)	936	WP_015057980.1	methionyl-tRNA formyltransferase	-

Sequence

Protein

• Length: 631 a.a.
• Molecular weight: 68725.11 Da
• Isoelectric Point: 7.2906

>NTDB_id=1016752 DQM44_RS08000 WP_022555036.1 1576463..1578358(-) (pknB) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC5370]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKNGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENHNVP
QALENVVIRATAKKLSDRYGSTFEMSRDLMTALSYNRSRERKVIFDDVESTKPLPKVTPAPVTTPKVAPTPVTSTTESRL
EHTNQMDTLQKPQKKKRNGRFLGTLLKILFSLFIVGVALFTYLVLTKPTSVKVPNVTGVSLKVAKQELQDLGLKVGKVRQ
IESDTVAEGNVVRTDPPTGTAKRKGSAITVYLSIGNKGFEMENYKGIDYQEAMASLMETYGVPKSKIKIERIVTNEYTEN
TVISQSPSAGDKFNPNGKSKITLSVAVSDTVIMPMVTEYTYADAVNTLTALGIEASRIKAYAPSSSSATGFVQINSPSSK
AIVSGQTPYYGTTLSLSEKGEISLYLYPEETHSSSSSTSSEASSSSSSTNDGTGTSSNTELSPSESAGQTP

Nucleotide

• Length: 1896 bp

>NTDB_id=1016752 DQM44_RS08000 WP_022555036.1 1576463..1578358(-) (pknB) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC5370]
ATGATTCAGATTGGCAAGTTATTTGCTGGTCGTTATCGCATTCTAAAATCTATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAATGATCTAATCTTGGATAATGAAGACGTTGCAATCAAGGTCTTACGTACCAATTATCAGACAGATCAGGTAG
CGGTTGCCCGTTTCCAACGGGAAGCGCGTGCCATGGCTGAGTTAAACCATCCTAATATTGTTGCCATCCGGGATATAGGT
GAAGAAGACGGACAGCAATTTTTAGTAATGGAATACGTAGATGGCGCTGACTTAAAGAAGTATATTCAAGATCATGCTCC
TCTATCCAATAATGAAGTGGTCAGAATCATGGAAGAGGTGCTTTCTGCCATGACATTAGCTCACCAGAAAGGGATTGTTC
ATAGAGATTTAAAACCTCAAAACATTCTTTTAACTAAAAATGGTGTGGTTAAGGTAACTGACTTTGGGATTGCCGTTGCT
TTTGCGGAAACGAGTTTGACTCAAACCAACTCTATGTTGGGAAGCGTCCATTACCTATCGCCTGAGCAGGCTCGCGGCTC
AAAAGCGACCATTCAAAGTGATATTTATGCGATGGGAATTATGCTCTTTGAAATGTTGACAGGACATATCCCTTATGATG
GCGATAGTGCTGTTACCATTGCTTTGCAACATTTCCAAAAGCCTCTTCCGTCTATTATTGACGAAAACCACAATGTACCG
CAAGCTTTAGAGAATGTGGTTATCCGAGCAACAGCTAAGAAATTAAGCGATCGTTACGGATCAACCTTTGAAATGAGTCG
TGATCTGATGACGGCTCTCAGTTACAACCGGAGTCGTGAACGGAAAGTTATTTTTGATGATGTGGAAAGCACAAAACCTC
TCCCTAAAGTAACACCGGCACCAGTAACGACGCCAAAAGTAGCTCCAACTCCTGTTACGTCCACAACTGAAAGTCGTTTA
GAACACACTAATCAGATGGATACGCTCCAGAAACCACAAAAAAAGAAGCGAAATGGTCGTTTCTTGGGTACTTTGTTAAA
AATCCTCTTTTCTCTTTTTATTGTAGGTGTGGCTCTCTTCACTTACTTGGTGCTAACAAAACCTACCTCAGTAAAAGTTC
CTAACGTGACAGGTGTCAGTCTTAAAGTTGCAAAGCAGGAACTGCAAGATTTAGGCTTGAAAGTTGGTAAGGTGAGACAG
ATTGAAAGTGATACTGTTGCGGAAGGGAATGTTGTCCGAACGGATCCACCAACGGGAACAGCCAAGCGCAAGGGTTCAGC
TATCACAGTTTACTTGTCAATTGGTAATAAAGGGTTTGAGATGGAAAACTACAAAGGGATTGATTATCAAGAAGCCATGG
CTAGCTTGATGGAAACTTACGGTGTTCCTAAATCGAAGATTAAGATTGAACGAATCGTGACCAATGAATACACGGAAAAT
ACTGTTATTAGCCAATCTCCGAGTGCAGGGGATAAATTTAATCCTAATGGGAAATCTAAAATTACTCTTAGTGTTGCCGT
GAGTGACACAGTCATTATGCCTATGGTAACAGAATATACCTATGCTGATGCAGTAAATACTTTGACAGCATTAGGTATTG
AAGCTTCAAGGATTAAAGCTTATGCTCCAAGCTCAAGTTCAGCAACAGGTTTTGTTCAGATTAATTCTCCAAGTTCAAAA
GCTATTGTCAGTGGTCAAACCCCTTATTACGGTACCACATTGAGCCTCTCTGAAAAAGGTGAGATAAGCCTTTACCTTTA
CCCAGAAGAAACGCATTCTTCAAGTAGTTCAACCAGTTCTGAGGCAAGTTCTAGCAGTTCCTCAACAAATGATGGAACGG
GAACAAGTAGTAATACTGAATTAAGCCCATCGGAATCAGCTGGTCAAACCCCTTAA

Domains

Predicted by InterProScan.

• Protein kinase domain (Pkinase) (12-233)

• PASTA domain (PASTA) (511-587)

• PASTA domain (PASTA) (440-505)

• PASTA domain (PASTA) (371-433)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pknB	Streptococcus mutans UA159	65.529	92.868	0.609
stkP/pknB	Streptococcus salivarius strain HSISS4	62.185	94.295	0.586
stkP	Streptococcus pneumoniae TIGR4	58.221	81.933	0.477
stkP	Streptococcus pneumoniae D39	58.027	81.933	0.475
stkP	Streptococcus pneumoniae R6	58.027	81.933	0.475
stkP	Streptococcus pneumoniae Rx1	57.834	81.933	0.474