Detailed information    

insolico Bioinformatically predicted

Overview


Name   comR/comR2   Type   Regulator
Locus tag   I6L84_RS00320 Genome accession   NZ_CP077224
Coordinates   65571..66053 (+) Length   160 a.a.
NCBI ID   WP_045772576.1    Uniprot ID   A0A0F3HQT1
Organism   Streptococcus gordonii strain FDAARGOS 1454     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 49106..74275 65571..66053 within 0


Gene organization within MGE regions


Location: 49106..74275
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6L84_RS00220 (I6L84_00220) htrA 49106..50299 (-) 1194 WP_060553296.1 S1C family serine protease Regulator
  I6L84_RS00225 (I6L84_00225) rlmH 50493..50972 (+) 480 WP_060553297.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6L84_RS00235 (I6L84_00235) comC/comC2 51259..51411 (+) 153 WP_008808033.1 bacteriocin Regulator
  I6L84_RS00240 (I6L84_00240) comD/comD2 51427..52785 (+) 1359 WP_060553298.1 competence system sensor histidine kinase ComD Regulator
  I6L84_RS00245 (I6L84_00245) comE/comE2 52782..53549 (+) 768 WP_008808031.1 competence system response regulator transcription factor ComE Regulator
  I6L84_RS00260 (I6L84_00260) ychF 53871..54986 (+) 1116 WP_008808030.1 redox-regulated ATPase YchF -
  I6L84_RS00265 (I6L84_00265) pth 55060..55629 (+) 570 WP_060553299.1 aminoacyl-tRNA hydrolase -
  I6L84_RS00270 (I6L84_00270) mfd 55622..59125 (+) 3504 WP_111705915.1 transcription-repair coupling factor -
  I6L84_RS00275 (I6L84_00275) - 59191..59457 (+) 267 WP_012131074.1 RNA-binding S4 domain-containing protein -
  I6L84_RS00280 (I6L84_00280) - 59450..59818 (+) 369 WP_012131073.1 septum formation initiator family protein -
  I6L84_RS00285 (I6L84_00285) - 59821..59940 (+) 120 WP_037622626.1 SP_0009 family protein -
  I6L84_RS00290 (I6L84_00290) - 59940..61220 (+) 1281 WP_045772579.1 serine hydrolase -
  I6L84_RS00295 (I6L84_00295) tilS 61217..62494 (+) 1278 WP_060553300.1 tRNA lysidine(34) synthetase TilS -
  I6L84_RS00300 (I6L84_00300) hpt 62499..63041 (+) 543 WP_060553301.1 hypoxanthine phosphoribosyltransferase -
  I6L84_RS00305 (I6L84_00305) ftsH 63060..65042 (+) 1983 WP_060553302.1 ATP-dependent zinc metalloprotease FtsH -
  I6L84_RS00320 (I6L84_00320) comR/comR2 65571..66053 (+) 483 WP_045772576.1 sigma-70 family RNA polymerase sigma factor Regulator
  I6L84_RS00430 (I6L84_00430) mreC 72958..73773 (+) 816 WP_060554277.1 rod shape-determining protein MreC -
  I6L84_RS00435 (I6L84_00435) mreD 73775..74275 (+) 501 WP_045773633.1 rod shape-determining protein MreD -

Sequence


Protein


Download         Length: 160 a.a.        Molecular weight: 19931.87 Da        Isoelectric Point: 9.4703

>NTDB_id=579992 I6L84_RS00320 WP_045772576.1 65571..66053(+) (comR/comR2) [Streptococcus gordonii strain FDAARGOS 1454]
MKFEDVYKQVEGIVKRCYKDYYLHLWEYADWRQEGMLVLYELLKSHPNLLEDHPRLYRYFKTKFRNRIHDLIRRQESQKR
KLDRQPYEEVSEIGHRLRMKELYLDELVAFRSAMAEYRSQLSPEESKQYERLMADERFKGRKAMLKDLSYHLRDFNPRLD

Nucleotide


Download         Length: 483 bp        

>NTDB_id=579992 I6L84_RS00320 WP_045772576.1 65571..66053(+) (comR/comR2) [Streptococcus gordonii strain FDAARGOS 1454]
ATGAAGTTTGAGGACGTATACAAACAAGTTGAAGGGATAGTCAAGCGCTGTTATAAAGATTATTATCTGCACTTATGGGA
GTATGCAGATTGGAGGCAGGAAGGAATGTTGGTGTTGTACGAATTATTAAAAAGTCATCCCAACCTACTGGAAGATCATC
CACGCCTGTACCGTTACTTCAAGACCAAGTTTCGGAACAGAATTCATGATTTGATTCGTCGCCAAGAGAGTCAAAAGCGG
AAATTGGACAGGCAACCCTATGAAGAGGTCAGCGAGATAGGTCATCGTTTAAGAATGAAAGAGCTGTATCTGGATGAATT
GGTAGCCTTTAGAAGTGCAATGGCAGAGTATAGAAGTCAGCTCAGTCCAGAAGAATCAAAACAATATGAGCGTCTGATGG
CAGATGAAAGGTTCAAAGGACGTAAGGCAATGCTCAAAGATTTGTCCTACCACTTAAGGGATTTCAATCCCCGTTTAGAT
TAA

Domains



No domain identified.



Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A0F3HQT1

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

97.5

100

0.975

  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

97.5

100

0.975

  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

50

97.5

0.488

  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

49.359

97.5

0.481

  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

49.359

97.5

0.481

  comX/comX1 Streptococcus pneumoniae Rx1

48.718

97.5

0.475

  comX/comX2 Streptococcus pneumoniae D39

48.718

97.5

0.475

  comX/comX1 Streptococcus pneumoniae D39

48.718

97.5

0.475

  comX/comX2 Streptococcus pneumoniae R6

48.718

97.5

0.475

  comX/comX1 Streptococcus pneumoniae R6

48.718

97.5

0.475

  comX/comX1 Streptococcus pneumoniae TIGR4

48.718

97.5

0.475

  comX/comX2 Streptococcus pneumoniae Rx1

48.718

97.5

0.475

  comX/comX2 Streptococcus pneumoniae TIGR4

48.718

97.5

0.475

  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

48.077

97.5

0.469

  comX/sigX Streptococcus suis P1/7

48.387

96.875

0.469

  comX/sigX Streptococcus suis D9

48.387

96.875

0.469

  comX/sigX Streptococcus suis isolate S10

48.387

96.875

0.469

  comX/sigX Streptococcus mutans UA159

47.436

97.5

0.463

  comX Streptococcus thermophilus LMG 18311

43.871

96.875

0.425

  comX Streptococcus thermophilus LMD-9

43.871

96.875

0.425

  comX/sigX Streptococcus salivarius strain HSISS4

43.226

96.875

0.419

  comX Streptococcus salivarius SK126

43.226

96.875

0.419

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

42.208

96.25

0.406

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

42.208

96.25

0.406

  comX Streptococcus sobrinus strain NIDR 6715-7

42.208

96.25

0.406

  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

40.506

98.75

0.4

  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

41.558

96.25

0.4

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

41.558

96.25

0.4

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

41.558

96.25

0.4

  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

41.558

96.25

0.4