Detailed information    

experimental Experimentally validated

Overview

Name   comX   Type   Regulator
Locus tag   DLJ51_RS00505 Genome accession   NZ_CP029560
Coordinates   83503..84126 (+) Length   207 a.a.
NCBI ID   WP_002962720.1    Uniprot ID   U2IUC9
Organism   Streptococcus sobrinus strain NIDR 6715-7     
Function   activation of late competence genes   
Competence regulation

Function

XIP increases the expression of the comX, ssbB, and cglA genes in strain NIDR 6715-7.


Genomic Context

Location: 78503..89126
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DLJ51_RS00505 (DLJ51_00505) comX 83503..84126 (+) 624 WP_002962720.1 sigma-70 family RNA polymerase sigma factor Regulator
  DLJ51_RS00510 (DLJ51_00510) rplM 84423..84869 (+) 447 WP_002962718.1 50S ribosomal protein L13 -
  DLJ51_RS00515 (DLJ51_00515) rpsI 84889..85281 (+) 393 WP_019775615.1 30S ribosomal protein S9 -
  DLJ51_RS00520 (DLJ51_00520) ruvB 85555..86553 (+) 999 WP_019769254.1 Holliday junction branch migration DNA helicase RuvB -
  DLJ51_RS00525 (DLJ51_00525) - 86598..87023 (+) 426 WP_002962714.1 low molecular weight protein-tyrosine-phosphatase -
  DLJ51_RS00530 (DLJ51_00530) - 87002..87436 (+) 435 WP_002962711.1 MORN repeat-containing protein -

Regulatory network

Positive effect      
Negative effect
Regulator Target Regulation
  comS comX positive effect
  comS comGA/cglA positive effect
  comS ssbB positive effect

Sequence

Protein


Download         Length: 207 a.a.        Molecular weight: 24561.19 Da        Isoelectric Point: 4.8066

>NTDB_id=582 DLJ51_RS00505 WP_002962720.1 83503..84126(+) (comX) [Streptococcus sobrinus strain NIDR 6715-7]
MDKEKLKEIFNKHSALPEEVEEFDDGMVKEVITAGLLFCLKEVLDMDDSSFVSAFSRVEKTVSKLAKDYYIKLWTYDDWR
QEARIILYQLLERFPDLANDEEKLRIYFKTKFRSYVLDNIRKQESQKRAFDRMIYEEISELGHMIPSQQMDTADYCALKE
KLKELKQKLAPEDYAKILLLMRGGAFKGRSAFIKDIKVEFEDFDEDN

Nucleotide


Download         Length: 624 bp        

>NTDB_id=582 DLJ51_RS00505 WP_002962720.1 83503..84126(+) (comX) [Streptococcus sobrinus strain NIDR 6715-7]
ATGGACAAAGAAAAACTCAAGGAAATTTTTAACAAACATTCTGCCTTACCAGAAGAAGTTGAAGAGTTTGATGATGGTAT
GGTCAAAGAAGTCATTACCGCTGGTTTATTATTTTGTTTGAAAGAGGTATTGGATATGGATGATTCTTCATTTGTAAGTG
CATTTAGCCGTGTTGAAAAGACTGTTAGCAAACTAGCTAAAGATTATTATATTAAATTATGGACCTATGATGACTGGAGG
CAGGAGGCACGAATTATCCTTTATCAGTTATTGGAGCGATTTCCAGATTTGGCCAATGATGAAGAAAAGTTACGAATCTA
TTTTAAAACAAAGTTCAGAAGTTATGTCCTTGATAATATTCGCAAGCAGGAAAGTCAAAAACGCGCTTTTGACAGGATGA
TTTACGAGGAAATTTCTGAATTAGGTCATATGATTCCTAGTCAGCAGATGGACACAGCTGATTATTGTGCCCTTAAGGAA
AAGCTAAAGGAACTTAAGCAGAAATTGGCTCCTGAGGATTATGCCAAAATTCTATTGCTGATGCGAGGTGGTGCATTCAA
AGGGAGAAGTGCCTTTATCAAGGATATTAAGGTTGAATTCGAAGATTTTGACGAGGACAACTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB U2IUC9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.


References

[1] J W Li et al. (2021) A Novel Competence Pathway in the Oral Pathogen Streptococcus sobrinus. Journal of Dental Research 100(5):542-548. [PMID: 33876976]