Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I6L84_RS00220 Genome accession   NZ_CP077224
Coordinates   49106..50299 (-) Length   397 a.a.
NCBI ID   WP_060553296.1    Uniprot ID   -
Organism   Streptococcus gordonii strain FDAARGOS 1454     
Function   repress competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 49106..74275 49106..50299 within 0


Gene organization within MGE regions


Location: 49106..74275
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6L84_RS00220 (I6L84_00220) htrA 49106..50299 (-) 1194 WP_060553296.1 S1C family serine protease Regulator
  I6L84_RS00225 (I6L84_00225) rlmH 50493..50972 (+) 480 WP_060553297.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6L84_RS00235 (I6L84_00235) comC/comC2 51259..51411 (+) 153 WP_008808033.1 bacteriocin Regulator
  I6L84_RS00240 (I6L84_00240) comD/comD2 51427..52785 (+) 1359 WP_060553298.1 competence system sensor histidine kinase ComD Regulator
  I6L84_RS00245 (I6L84_00245) comE/comE2 52782..53549 (+) 768 WP_008808031.1 competence system response regulator transcription factor ComE Regulator
  I6L84_RS00260 (I6L84_00260) ychF 53871..54986 (+) 1116 WP_008808030.1 redox-regulated ATPase YchF -
  I6L84_RS00265 (I6L84_00265) pth 55060..55629 (+) 570 WP_060553299.1 aminoacyl-tRNA hydrolase -
  I6L84_RS00270 (I6L84_00270) mfd 55622..59125 (+) 3504 WP_111705915.1 transcription-repair coupling factor -
  I6L84_RS00275 (I6L84_00275) - 59191..59457 (+) 267 WP_012131074.1 RNA-binding S4 domain-containing protein -
  I6L84_RS00280 (I6L84_00280) - 59450..59818 (+) 369 WP_012131073.1 septum formation initiator family protein -
  I6L84_RS00285 (I6L84_00285) - 59821..59940 (+) 120 WP_037622626.1 SP_0009 family protein -
  I6L84_RS00290 (I6L84_00290) - 59940..61220 (+) 1281 WP_045772579.1 serine hydrolase -
  I6L84_RS00295 (I6L84_00295) tilS 61217..62494 (+) 1278 WP_060553300.1 tRNA lysidine(34) synthetase TilS -
  I6L84_RS00300 (I6L84_00300) hpt 62499..63041 (+) 543 WP_060553301.1 hypoxanthine phosphoribosyltransferase -
  I6L84_RS00305 (I6L84_00305) ftsH 63060..65042 (+) 1983 WP_060553302.1 ATP-dependent zinc metalloprotease FtsH -
  I6L84_RS00320 (I6L84_00320) comR/comR2 65571..66053 (+) 483 WP_045772576.1 sigma-70 family RNA polymerase sigma factor Regulator
  I6L84_RS00430 (I6L84_00430) mreC 72958..73773 (+) 816 WP_060554277.1 rod shape-determining protein MreC -
  I6L84_RS00435 (I6L84_00435) mreD 73775..74275 (+) 501 WP_045773633.1 rod shape-determining protein MreD -

Sequence

Protein


Download         Length: 397 a.a.        Molecular weight: 42209.90 Da        Isoelectric Point: 5.4898

>NTDB_id=579988 I6L84_RS00220 WP_060553296.1 49106..50299(-) (htrA) [Streptococcus gordonii strain FDAARGOS 1454]
MKNSSNFFKKTLQVFIVLLVGFIGGVAGTWGFSYFSTPHSATNNNQKTATTITTSYKNSNSTTKAVDKVKDAVVSVITYS
ESNSDAIFDNNNSGNENDQVASEGSGVIYRKDKDYAYLVTNTHVINGAKKVDIRLADGNKVPGEIVGTDTYSDISVVRIP
ADKVKNVAEFGDSSKLTVGETAIAIGSPLGSDYANTVTQGIVSSLSRNVSSRSEDGQTIATQAIQTDAAINPGNSGGPLV
NIQGQVIGITSSKIANTNNGSTSVEGMGFAIPSNDVVNIIEQLEKNGKVIRPALGIQMVNLSSLSSSSSDRLKLPDNIKN
GVVVRSTQTGMPADGKLQKYDVITKIDDTEISSASDIQSALYKHSINEEIKVTYYRDGKEQTTTIKLTKSTDDLSSE

Nucleotide


Download         Length: 1194 bp        

>NTDB_id=579988 I6L84_RS00220 WP_060553296.1 49106..50299(-) (htrA) [Streptococcus gordonii strain FDAARGOS 1454]
ATGAAAAACTCTTCAAATTTCTTCAAAAAAACATTGCAAGTTTTCATTGTTTTGTTAGTTGGTTTTATAGGTGGTGTTGC
TGGAACATGGGGATTTTCTTATTTTTCAACACCTCATTCAGCCACAAATAATAATCAGAAAACAGCGACTACAATAACAA
CATCCTATAAAAATAGTAATTCTACAACAAAGGCTGTTGATAAAGTAAAAGACGCGGTTGTCTCTGTCATTACATATTCT
GAATCTAATTCAGATGCTATTTTTGACAACAATAATTCAGGAAATGAAAATGATCAGGTAGCTAGCGAAGGATCTGGTGT
TATCTATAGAAAAGATAAAGACTATGCTTACTTAGTTACCAATACACACGTTATCAATGGTGCAAAAAAAGTTGATATCC
GTCTTGCTGATGGGAATAAGGTTCCTGGTGAAATAGTCGGGACTGATACATATTCTGATATTTCTGTAGTCAGAATTCCT
GCTGATAAAGTAAAAAATGTAGCAGAATTTGGGGATTCTAGTAAATTAACTGTTGGGGAAACTGCCATTGCAATCGGAAG
TCCTCTTGGATCTGATTATGCTAATACAGTGACTCAGGGGATTGTTTCCAGCCTAAGCCGTAATGTTTCTTCACGATCAG
AAGATGGTCAAACAATTGCTACTCAAGCTATTCAAACTGATGCAGCAATTAATCCAGGTAACTCTGGTGGTCCTCTTGTA
AACATTCAAGGTCAAGTTATTGGTATTACCTCTAGTAAAATTGCTAACACCAATAATGGTAGTACTTCTGTTGAAGGTAT
GGGATTTGCAATACCATCCAATGATGTTGTAAATATCATTGAACAATTAGAAAAGAATGGAAAAGTCATTCGACCAGCAT
TAGGAATTCAAATGGTCAACTTAAGTAGTTTGTCTTCTTCAAGCTCTGATCGATTAAAACTTCCAGACAATATTAAGAAT
GGTGTCGTTGTTCGTTCCACACAAACTGGAATGCCTGCTGATGGTAAGTTACAAAAATATGATGTGATTACAAAAATTGA
TGATACAGAAATATCATCTGCTAGCGATATCCAATCAGCTCTTTATAAACATTCAATTAATGAAGAAATTAAAGTTACTT
ATTATCGTGATGGAAAAGAGCAAACAACAACTATTAAACTAACTAAATCAACTGATGATTTAAGTTCTGAATAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

PDZ domain (PDZ_2)

(292-387)

Peptidase family M50 (Peptidase_M50)

(236-391)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

98.992

100

0.99
  htrA Streptococcus mitis NCTC 12261

65.829

100

0.66
  htrA Streptococcus pneumoniae Rx1

65.909

99.748

0.657
  htrA Streptococcus pneumoniae D39

65.909

99.748

0.657
  htrA Streptococcus pneumoniae R6

65.909

99.748

0.657
  htrA Streptococcus pneumoniae TIGR4

65.909

99.748

0.657
  htrA Streptococcus mutans UA159

55.89

100

0.562