Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/comE2   Type   Regulator
Locus tag   I6L84_RS00245 Genome accession   NZ_CP077224
Coordinates   52782..53549 (+) Length   255 a.a.
NCBI ID   WP_008808031.1    Uniprot ID   P75031
Organism   Streptococcus gordonii strain FDAARGOS 1454     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 49106..74275 52782..53549 within 0


Gene organization within MGE regions


Location: 49106..74275
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6L84_RS00220 (I6L84_00220) htrA 49106..50299 (-) 1194 WP_060553296.1 S1C family serine protease Regulator
  I6L84_RS00225 (I6L84_00225) rlmH 50493..50972 (+) 480 WP_060553297.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6L84_RS00235 (I6L84_00235) comC/comC2 51259..51411 (+) 153 WP_008808033.1 bacteriocin Regulator
  I6L84_RS00240 (I6L84_00240) comD/comD2 51427..52785 (+) 1359 WP_060553298.1 competence system sensor histidine kinase ComD Regulator
  I6L84_RS00245 (I6L84_00245) comE/comE2 52782..53549 (+) 768 WP_008808031.1 competence system response regulator transcription factor ComE Regulator
  I6L84_RS00260 (I6L84_00260) ychF 53871..54986 (+) 1116 WP_008808030.1 redox-regulated ATPase YchF -
  I6L84_RS00265 (I6L84_00265) pth 55060..55629 (+) 570 WP_060553299.1 aminoacyl-tRNA hydrolase -
  I6L84_RS00270 (I6L84_00270) mfd 55622..59125 (+) 3504 WP_111705915.1 transcription-repair coupling factor -
  I6L84_RS00275 (I6L84_00275) - 59191..59457 (+) 267 WP_012131074.1 RNA-binding S4 domain-containing protein -
  I6L84_RS00280 (I6L84_00280) - 59450..59818 (+) 369 WP_012131073.1 septum formation initiator family protein -
  I6L84_RS00285 (I6L84_00285) - 59821..59940 (+) 120 WP_037622626.1 SP_0009 family protein -
  I6L84_RS00290 (I6L84_00290) - 59940..61220 (+) 1281 WP_045772579.1 serine hydrolase -
  I6L84_RS00295 (I6L84_00295) tilS 61217..62494 (+) 1278 WP_060553300.1 tRNA lysidine(34) synthetase TilS -
  I6L84_RS00300 (I6L84_00300) hpt 62499..63041 (+) 543 WP_060553301.1 hypoxanthine phosphoribosyltransferase -
  I6L84_RS00305 (I6L84_00305) ftsH 63060..65042 (+) 1983 WP_060553302.1 ATP-dependent zinc metalloprotease FtsH -
  I6L84_RS00320 (I6L84_00320) comR/comR2 65571..66053 (+) 483 WP_045772576.1 sigma-70 family RNA polymerase sigma factor Regulator
  I6L84_RS00430 (I6L84_00430) mreC 72958..73773 (+) 816 WP_060554277.1 rod shape-determining protein MreC -
  I6L84_RS00435 (I6L84_00435) mreD 73775..74275 (+) 501 WP_045773633.1 rod shape-determining protein MreD -

Sequence

Protein


Download         Length: 255 a.a.        Molecular weight: 30225.48 Da        Isoelectric Point: 7.0651

>NTDB_id=579991 I6L84_RS00245 WP_008808031.1 52782..53549(+) (comE/comE2) [Streptococcus gordonii strain FDAARGOS 1454]
MKVLVLEDTIEHQVRIENVFEEISRELNLEIKAKVTGKIHEFKEYVESDEVNQLYFLDIDIKGEEQKGLEMAQFIRQHNP
YAIIVFVTSHSEFATLTFKYKVSALDFIDKDINDNSFKKRVKDCIVYTRNNLIENTDIVDFFEYSFRGNEIRIPFRDILY
IETTGSPYKLRVVGKNFFKEFYGTIAEIQEQDKELGYFFSPHKSYLSNISNISGYDKKTKDVLYYDGHRSPISRLRVRYL
KEILKAKSKKEENKK

Nucleotide


Download         Length: 768 bp        

>NTDB_id=579991 I6L84_RS00245 WP_008808031.1 52782..53549(+) (comE/comE2) [Streptococcus gordonii strain FDAARGOS 1454]
ATGAAAGTATTAGTGCTAGAAGATACTATTGAACATCAAGTGAGAATTGAAAATGTCTTCGAAGAAATTTCTCGCGAACT
TAATCTTGAAATTAAAGCAAAAGTAACAGGAAAAATTCATGAATTTAAAGAATATGTTGAGTCAGACGAGGTAAATCAAC
TCTATTTCTTAGATATAGATATCAAAGGAGAAGAACAAAAAGGTCTAGAAATGGCCCAATTTATACGCCAACATAATCCC
TATGCTATCATTGTTTTTGTTACGAGTCATTCAGAATTTGCGACCTTAACTTTTAAGTATAAAGTATCAGCGTTAGATTT
TATAGACAAAGACATAAATGATAATTCTTTTAAGAAAAGAGTTAAAGATTGCATCGTTTATACACGAAATAATTTAATTG
AAAATACAGATATTGTTGACTTTTTTGAGTATAGTTTTAGAGGAAACGAAATTCGAATTCCTTTTAGAGATATTTTATAT
ATTGAGACAACAGGAAGTCCTTATAAATTAAGAGTTGTTGGAAAAAATTTCTTTAAGGAATTCTATGGAACAATAGCAGA
AATTCAGGAACAAGATAAAGAACTTGGATATTTTTTCTCACCACACAAGTCATACCTATCTAATATTAGTAATATTAGTG
GATACGACAAAAAAACAAAAGATGTTTTGTATTATGATGGTCATCGTTCACCAATTTCTCGATTACGTGTCAGATATTTA
AAAGAAATACTGAAAGCAAAAAGTAAAAAAGAAGAAAATAAAAAATAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-244)

Response regulator receiver domain (Response_reg)

(3-121)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P75031

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/comE2 Streptococcus gordonii strain NCTC7865

100

100

1
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

100

100

1
  comE Streptococcus infantis strain Atu-4

64

98.039

0.627
  comE Streptococcus mitis NCTC 12261

64

98.039

0.627
  comE Streptococcus mitis SK321

63.2

98.039

0.62
  comE Streptococcus pneumoniae Rx1

62.8

98.039

0.616
  comE Streptococcus pneumoniae D39

62.8

98.039

0.616
  comE Streptococcus pneumoniae R6

62.8

98.039

0.616
  comE Streptococcus pneumoniae TIGR4

62.8

98.039

0.616
  comE/blpR Streptococcus mutans UA159

37.551

96.078

0.361