Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4633070..4633884 Replicon chromosome
Accession NC_010473
Organism Escherichia coli str. K-12 substr. DH10B

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag ECDH10B_RS22990 Protein ID WP_001054376.1
Coordinates 4633627..4633884 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag ECDH10B_RS22985 Protein ID WP_001309181.1
Coordinates 4633070..4633615 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECDH10B_RS22965 (ECDH10B_4505) 4628761..4630074 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
ECDH10B_RS22970 (ECDH10B_4506) 4630086..4630364 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
ECDH10B_RS22975 (ECDH10B_4507) 4630361..4631482 - 1122 WP_000010829.1 M42 family metallopeptidase -
ECDH10B_RS26330 4631727..4631843 - 117 Protein_4353 VOC family protein -
ECDH10B_RS25810 4631881..4632099 - 219 Protein_4354 hypothetical protein -
ECDH10B_RS22980 (ECDH10B_4508) 4632268..4633014 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
ECDH10B_RS22985 (ECDH10B_4509) 4633070..4633615 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
ECDH10B_RS22990 (ECDH10B_4510) 4633627..4633884 - 258 WP_001054376.1 hypothetical protein Toxin
ECDH10B_RS26170 4634261..4634506 - 246 Protein_4358 GNAT family N-acetyltransferase -
ECDH10B_RS23005 (ECDH10B_4511) 4634622..4635862 + 1241 Protein_4359 helicase YjhR -
ECDH10B_RS23010 (ECDH10B_4512) 4636445..4637425 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ECDH10B_RS23015 (ECDH10B_4513) 4637490..4638596 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4633070..4649322 16252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T22706 WP_001054376.1 NC_010473:c4633884-4633627 [Escherichia coli str. K-12 substr. DH10B]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T22706 NC_010473:c4633884-4633627 [Escherichia coli str. K-12 substr. DH10B]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT22706 WP_001309181.1 NC_010473:c4633615-4633070 [Escherichia coli str. K-12 substr. DH10B]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT22706 NC_010473:c4633615-4633070 [Escherichia coli str. K-12 substr. DH10B]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References