Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3999698..4000512 Replicon chromosome
Accession NZ_CP114896
Organism Escherichia coli strain CM93

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag O6117_RS19515 Protein ID WP_001054376.1
Coordinates 4000255..4000512 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag O6117_RS19510 Protein ID WP_001309181.1
Coordinates 3999698..4000243 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6117_RS19480 (3995389) 3995389..3996702 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
O6117_RS19485 (3996714) 3996714..3996992 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
O6117_RS19490 (3996989) 3996989..3998110 - 1122 WP_000010829.1 M42 family metallopeptidase -
O6117_RS19495 (3998355) 3998355..3998471 - 117 Protein_3789 VOC family protein -
O6117_RS19500 (3998509) 3998509..3998727 - 219 Protein_3790 hypothetical protein -
O6117_RS19505 (3998896) 3998896..3999642 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
O6117_RS19510 (3999698) 3999698..4000243 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
O6117_RS19515 (4000255) 4000255..4000512 - 258 WP_001054376.1 YjhX family toxin Toxin
O6117_RS19520 (4001003) 4001003..4001134 - 132 WP_001309182.1 hypothetical protein -
O6117_RS19525 (4001250) 4001250..4002490 + 1241 Protein_3795 helicase YjhR -
O6117_RS19530 (4002758) 4002758..4002963 - 206 Protein_3796 HNH endonuclease -
O6117_RS19535 (4003073) 4003073..4004053 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
O6117_RS19540 (4004118) 4004118..4005224 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3999698..4015950 16252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T267037 WP_001054376.1 NZ_CP114896:c4000512-4000255 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT267037 WP_001309181.1 NZ_CP114896:c4000243-3999698 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References