Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4635171..4635985 Replicon chromosome
Accession NZ_CP110014
Organism Escherichia coli strain HE_100-10

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag OLR77_RS22705 Protein ID WP_001054376.1
Coordinates 4635728..4635985 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag OLR77_RS22700 Protein ID WP_001309181.1
Coordinates 4635171..4635716 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR77_RS22670 (4630862) 4630862..4632175 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
OLR77_RS22675 (4632187) 4632187..4632465 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
OLR77_RS22680 (4632462) 4632462..4633583 - 1122 WP_000010829.1 M42 family metallopeptidase -
OLR77_RS22685 (4633828) 4633828..4633944 - 117 Protein_4417 VOC family protein -
OLR77_RS22690 (4633982) 4633982..4634200 - 219 Protein_4418 hypothetical protein -
OLR77_RS22695 (4634369) 4634369..4635115 - 747 WP_282992804.1 class I SAM-dependent methyltransferase -
OLR77_RS22700 (4635171) 4635171..4635716 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
OLR77_RS22705 (4635728) 4635728..4635985 - 258 WP_001054376.1 YjhX family toxin Toxin
OLR77_RS22710 (4636476) 4636476..4636607 - 132 WP_001309182.1 hypothetical protein -
OLR77_RS22715 (4636723) 4636723..4637963 + 1241 Protein_4423 helicase YjhR -
OLR77_RS22720 (4638231) 4638231..4638436 - 206 Protein_4424 HNH endonuclease -
OLR77_RS22725 (4638546) 4638546..4639526 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
OLR77_RS22730 (4639591) 4639591..4640696 - 1106 Protein_4426 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4635171..4651422 16251


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T262657 WP_001054376.1 NZ_CP110014:c4635985-4635728 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT262657 WP_001309181.1 NZ_CP110014:c4635716-4635171 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References