266985

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3901022..3901836 Replicon chromosome
Accession NZ_CP114894
Organism Escherichia coli strain CM19

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag O6X69_RS19065 Protein ID WP_001054376.1
Coordinates 3901579..3901836 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag O6X69_RS19060 Protein ID WP_001309181.1
Coordinates 3901022..3901567 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6X69_RS19030 (3896713) 3896713..3898026 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
O6X69_RS19035 (3898038) 3898038..3898316 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
O6X69_RS19040 (3898313) 3898313..3899434 - 1122 WP_000010829.1 M42 family metallopeptidase -
O6X69_RS19045 (3899679) 3899679..3899795 - 117 Protein_3699 VOC family protein -
O6X69_RS19050 (3899833) 3899833..3900051 - 219 Protein_3700 hypothetical protein -
O6X69_RS19055 (3900220) 3900220..3900966 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
O6X69_RS19060 (3901022) 3901022..3901567 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
O6X69_RS19065 (3901579) 3901579..3901836 - 258 WP_001054376.1 YjhX family toxin Toxin
O6X69_RS19070 (3902327) 3902327..3902458 - 132 WP_001309182.1 hypothetical protein -
O6X69_RS19075 (3902574) 3902574..3903814 + 1241 Protein_3705 helicase YjhR -
O6X69_RS19080 (3904082) 3904082..3904287 - 206 Protein_3706 HNH endonuclease -
O6X69_RS19085 (3904397) 3904397..3905377 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
O6X69_RS19090 (3905442) 3905442..3906548 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3893335..3917274 23939


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T266985 WP_001054376.1 NZ_CP114894:c3901836-3901579 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT266985 WP_001309181.1 NZ_CP114894:c3901567-3901022 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References