Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4635183..4635997 Replicon chromosome
Accession NZ_CP110015
Organism Escherichia coli strain HE_150

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag OLR73_RS22700 Protein ID WP_001054376.1
Coordinates 4635740..4635997 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag OLR73_RS22695 Protein ID WP_001309181.1
Coordinates 4635183..4635728 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR73_RS22665 (4630874) 4630874..4632187 - 1314 WP_283012230.1 PTS sugar transporter subunit IIC SgcC -
OLR73_RS22670 (4632199) 4632199..4632477 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
OLR73_RS22675 (4632474) 4632474..4633595 - 1122 WP_000010829.1 M42 family metallopeptidase -
OLR73_RS22680 (4633840) 4633840..4633956 - 117 Protein_4416 VOC family protein -
OLR73_RS22685 (4633994) 4633994..4634212 - 219 Protein_4417 hypothetical protein -
OLR73_RS22690 (4634381) 4634381..4635127 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
OLR73_RS22695 (4635183) 4635183..4635728 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
OLR73_RS22700 (4635740) 4635740..4635997 - 258 WP_001054376.1 YjhX family toxin Toxin
OLR73_RS22705 (4636488) 4636488..4636619 - 132 WP_001309182.1 hypothetical protein -
OLR73_RS22710 (4636735) 4636735..4637975 + 1241 Protein_4422 helicase YjhR -
OLR73_RS22715 (4638243) 4638243..4638448 - 206 Protein_4423 HNH endonuclease -
OLR73_RS22720 (4638558) 4638558..4639538 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
OLR73_RS22725 (4639603) 4639603..4640708 - 1106 Protein_4425 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4635183..4651434 16251


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T262683 WP_001054376.1 NZ_CP110015:c4635997-4635740 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT262683 WP_001309181.1 NZ_CP110015:c4635728-4635183 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References