266936

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3767291..3768105 Replicon chromosome
Accession NZ_CP114892
Organism Escherichia coli strain CM5

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag O6Q95_RS18405 Protein ID WP_001054376.1
Coordinates 3767848..3768105 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag O6Q95_RS18400 Protein ID WP_001309181.1
Coordinates 3767291..3767836 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6Q95_RS18370 (3762982) 3762982..3764295 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
O6Q95_RS18375 (3764307) 3764307..3764585 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
O6Q95_RS18380 (3764582) 3764582..3765703 - 1122 WP_000010829.1 M42 family metallopeptidase -
O6Q95_RS18385 (3765948) 3765948..3766064 - 117 Protein_3582 VOC family protein -
O6Q95_RS18390 (3766102) 3766102..3766320 - 219 Protein_3583 hypothetical protein -
O6Q95_RS18395 (3766489) 3766489..3767235 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
O6Q95_RS18400 (3767291) 3767291..3767836 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
O6Q95_RS18405 (3767848) 3767848..3768105 - 258 WP_001054376.1 YjhX family toxin Toxin
O6Q95_RS18410 (3768596) 3768596..3768727 - 132 WP_001309182.1 hypothetical protein -
O6Q95_RS18415 (3768843) 3768843..3770083 + 1241 Protein_3588 helicase YjhR -
O6Q95_RS18420 (3770351) 3770351..3770556 - 206 Protein_3589 HNH endonuclease -
O6Q95_RS18425 (3770666) 3770666..3771646 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
O6Q95_RS18430 (3771711) 3771711..3772817 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3767291..3783543 16252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T266936 WP_001054376.1 NZ_CP114892:c3768105-3767848 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT266936 WP_001309181.1 NZ_CP114892:c3767836-3767291 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References