Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4635178..4635992 Replicon chromosome
Accession NZ_CP110016
Organism Escherichia coli strain HE_100

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag OLR74_RS22710 Protein ID WP_001054376.1
Coordinates 4635735..4635992 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag OLR74_RS22705 Protein ID WP_001309181.1
Coordinates 4635178..4635723 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR74_RS22675 (4630869) 4630869..4632182 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
OLR74_RS22680 (4632194) 4632194..4632472 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
OLR74_RS22685 (4632469) 4632469..4633590 - 1122 WP_000010829.1 M42 family metallopeptidase -
OLR74_RS22690 (4633835) 4633835..4633951 - 117 Protein_4418 VOC family protein -
OLR74_RS22695 (4633989) 4633989..4634207 - 219 Protein_4419 hypothetical protein -
OLR74_RS22700 (4634376) 4634376..4635122 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
OLR74_RS22705 (4635178) 4635178..4635723 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
OLR74_RS22710 (4635735) 4635735..4635992 - 258 WP_001054376.1 YjhX family toxin Toxin
OLR74_RS22715 (4636483) 4636483..4636614 - 132 WP_001309182.1 hypothetical protein -
OLR74_RS22720 (4636730) 4636730..4637970 + 1241 Protein_4424 helicase YjhR -
OLR74_RS22725 (4638238) 4638238..4638443 - 206 Protein_4425 HNH endonuclease -
OLR74_RS22730 (4638553) 4638553..4639533 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
OLR74_RS22735 (4639598) 4639598..4640703 - 1106 Protein_4427 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4635178..4651429 16251


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T262709 WP_001054376.1 NZ_CP110016:c4635992-4635735 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT262709 WP_001309181.1 NZ_CP110016:c4635723-4635178 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References