262761

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4634420..4635234 Replicon chromosome
Accession NZ_CP110018
Organism Escherichia coli strain DH10B

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag OLR78_RS22690 Protein ID WP_001054376.1
Coordinates 4634977..4635234 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag OLR78_RS22685 Protein ID WP_001309181.1
Coordinates 4634420..4634965 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR78_RS22655 (4630111) 4630111..4631424 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
OLR78_RS22660 (4631436) 4631436..4631714 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
OLR78_RS22665 (4631711) 4631711..4632832 - 1122 WP_000010829.1 M42 family metallopeptidase -
OLR78_RS22670 (4633077) 4633077..4633193 - 117 Protein_4414 VOC family protein -
OLR78_RS22675 (4633231) 4633231..4633449 - 219 Protein_4415 hypothetical protein -
OLR78_RS22680 (4633618) 4633618..4634364 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
OLR78_RS22685 (4634420) 4634420..4634965 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
OLR78_RS22690 (4634977) 4634977..4635234 - 258 WP_001054376.1 YjhX family toxin Toxin
OLR78_RS22695 (4635725) 4635725..4635856 - 132 WP_001309182.1 hypothetical protein -
OLR78_RS22700 (4635972) 4635972..4637212 + 1241 Protein_4420 helicase YjhR -
OLR78_RS22705 (4637480) 4637480..4637685 - 206 Protein_4421 HNH endonuclease -
OLR78_RS22710 (4637795) 4637795..4638775 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
OLR78_RS22715 (4638840) 4638840..4639946 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4634420..4650672 16252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T262761 WP_001054376.1 NZ_CP110018:c4635234-4634977 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT262761 WP_001309181.1 NZ_CP110018:c4634965-4634420 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References