Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 611516..612330 Replicon chromosome
Accession NZ_CP114895
Organism Escherichia coli strain CM56

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag O6106_RS02920 Protein ID WP_001054376.1
Coordinates 612073..612330 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag O6106_RS02915 Protein ID WP_001309181.1
Coordinates 611516..612061 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6106_RS02885 (607207) 607207..608520 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
O6106_RS02890 (608532) 608532..608810 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
O6106_RS02895 (608807) 608807..609928 - 1122 WP_000010829.1 M42 family metallopeptidase -
O6106_RS02900 (610173) 610173..610289 - 117 Protein_547 VOC family protein -
O6106_RS02905 (610327) 610327..610545 - 219 Protein_548 hypothetical protein -
O6106_RS02910 (610714) 610714..611460 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
O6106_RS02915 (611516) 611516..612061 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
O6106_RS02920 (612073) 612073..612330 - 258 WP_001054376.1 YjhX family toxin Toxin
O6106_RS02925 (612821) 612821..612952 - 132 WP_001309182.1 hypothetical protein -
O6106_RS02930 (613068) 613068..614308 + 1241 Protein_553 helicase YjhR -
O6106_RS02935 (614576) 614576..614781 - 206 Protein_554 HNH endonuclease -
O6106_RS02940 (614891) 614891..615871 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
O6106_RS02945 (615936) 615936..617042 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 611516..627768 16252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T266992 WP_001054376.1 NZ_CP114895:c612330-612073 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT266992 WP_001309181.1 NZ_CP114895:c612061-611516 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References