262735

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4635185..4635999 Replicon chromosome
Accession NZ_CP110017
Organism Escherichia coli strain HE_50

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag OLR76_RS22700 Protein ID WP_001054376.1
Coordinates 4635742..4635999 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag OLR76_RS22695 Protein ID WP_001309181.1
Coordinates 4635185..4635730 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR76_RS22665 (4630876) 4630876..4632189 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
OLR76_RS22670 (4632201) 4632201..4632479 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
OLR76_RS22675 (4632476) 4632476..4633597 - 1122 WP_000010829.1 M42 family metallopeptidase -
OLR76_RS22680 (4633842) 4633842..4633958 - 117 Protein_4416 VOC family protein -
OLR76_RS22685 (4633996) 4633996..4634214 - 219 Protein_4417 hypothetical protein -
OLR76_RS22690 (4634383) 4634383..4635129 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
OLR76_RS22695 (4635185) 4635185..4635730 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
OLR76_RS22700 (4635742) 4635742..4635999 - 258 WP_001054376.1 YjhX family toxin Toxin
OLR76_RS22705 (4636490) 4636490..4636621 - 132 WP_001309182.1 hypothetical protein -
OLR76_RS22710 (4636737) 4636737..4637977 + 1241 Protein_4422 helicase YjhR -
OLR76_RS22715 (4638245) 4638245..4638450 - 206 Protein_4423 HNH endonuclease -
OLR76_RS22720 (4638560) 4638560..4639540 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
OLR76_RS22725 (4639605) 4639605..4640711 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4635185..4651437 16252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T262735 WP_001054376.1 NZ_CP110017:c4635999-4635742 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT262735 WP_001309181.1 NZ_CP110017:c4635730-4635185 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References