Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2037467..2037766 Replicon chromosome
Accession NC_007795
Organism Staphylococcus aureus subsp. aureus NCTC 8325

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag SAOUHSC_02176 Protein ID YP_500662.1
Coordinates 2037590..2037766 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2037467..2037522 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAOUHSC_02166 2032800..2033060 + 261 YP_500654.1 hypothetical protein -
SAOUHSC_02167 2033113..2033463 - 351 YP_500655.1 hypothetical protein -
SAOUHSC_02169 2034146..2034595 + 450 YP_500656.1 chemotaxis-inhibiting protein CHIPS -
SAOUHSC_02170 2034690..2034986 - 297 YP_500657.1 peptidoglycan hydrolase -
SAOUHSC_02171 2035675..2036166 - 492 YP_500658.1 staphylokinase -
SAOUHSC_02173 2036357..2037112 - 756 YP_500659.1 amidase -
SAOUHSC_02174 2037124..2037378 - 255 YP_500660.1 phage phi LC3 family holin -
SAOUHSC_02175 2037430..2037537 + 108 YP_500661.1 hypothetical protein -
- 2037467..2037522 + 56 - - Antitoxin
SAOUHSC_02176 2037590..2037766 - 177 YP_500662.1 hypothetical protein Toxin
SAOUHSC_02177 2037916..2038212 - 297 YP_500663.1 hypothetical protein -
SAOUHSC_02178 2038270..2038557 - 288 YP_500664.1 phi PVL orf 22-like protein -
SAOUHSC_02179 2038604..2038756 - 153 YP_500665.1 hypothetical protein -
SAOUHSC_02180 2038746..2042531 - 3786 YP_500666.1 phage minor structural protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / hlb / groEL 2033113..2088736 55623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T21487 YP_500662.1 NC_007795:c2037766-2037590 [Staphylococcus aureus subsp. aureus NCTC 8325]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T21487 NC_007795:c2037766-2037590 [Staphylococcus aureus subsp. aureus NCTC 8325]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT21487 NC_007795:2037467-2037522 [Staphylococcus aureus subsp. aureus NCTC 8325]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References