Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2039530..2039837 Replicon chromosome
Accession NZ_CP069799
Organism Staphylococcus aureus strain 014S_SA

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag JS513_RS10085 Protein ID WP_011447039.1
Coordinates 2039661..2039837 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2039530..2039669 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JS513_RS10045 2034871..2035131 + 261 WP_001791826.1 hypothetical protein -
JS513_RS10050 2035184..2035534 - 351 WP_000702262.1 complement inhibitor SCIN-A -
JS513_RS10055 2036217..2036666 + 450 WP_000727643.1 chemotaxis-inhibiting protein CHIPS -
JS513_RS10060 2036761..2037096 - 336 Protein_1943 SH3 domain-containing protein -
JS513_RS10065 2037746..2038237 - 492 WP_000920037.1 staphylokinase -
JS513_RS10070 2038428..2039183 - 756 WP_000861038.1 CHAP domain-containing protein -
JS513_RS10075 2039195..2039449 - 255 WP_000611512.1 phage holin -
JS513_RS10080 2039501..2039608 + 108 WP_001791821.1 hypothetical protein -
- 2039530..2039669 + 140 NuclAT_0 - Antitoxin
- 2039530..2039669 + 140 NuclAT_0 - Antitoxin
- 2039530..2039669 + 140 NuclAT_0 - Antitoxin
- 2039530..2039669 + 140 NuclAT_0 - Antitoxin
JS513_RS10085 2039661..2039837 - 177 WP_011447039.1 putative holin-like toxin Toxin
JS513_RS10090 2039987..2040283 - 297 WP_000539688.1 DUF2951 domain-containing protein -
JS513_RS10095 2040341..2040628 - 288 WP_001040261.1 hypothetical protein -
JS513_RS10100 2040675..2040827 - 153 WP_001153681.1 hypothetical protein -
JS513_RS10105 2040817..2044602 - 3786 WP_047230708.1 phage minor structural protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / hlb / groEL 2035184..2087431 52247


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T191814 WP_011447039.1 NZ_CP069799:c2039837-2039661 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T191814 NZ_CP091925:1762133-1762384 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 140 bp

>AT191814 NZ_CP069799:2039530-2039669 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References