Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 1819350..1819688 Replicon chromosome
Accession NZ_CP026070
Organism Staphylococcus aureus strain FDAARGOS_27

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag RK85_RS09470 Protein ID WP_011447039.1
Coordinates 1819350..1819526 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1819514..1819688 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK85_RS09450 1814585..1818370 + 3786 WP_000582137.1 hypothetical protein -
RK85_RS09455 1818360..1818512 + 153 WP_001153681.1 hypothetical protein -
RK85_RS09460 1818559..1818846 + 288 WP_001040261.1 hypothetical protein -
RK85_RS09465 1818904..1819200 + 297 WP_000539688.1 DUF2951 domain-containing protein -
RK85_RS09470 1819350..1819526 + 177 WP_011447039.1 putative holin-like toxin Toxin
- 1819514..1819688 - 175 - - Antitoxin
RK85_RS09480 1819738..1819992 + 255 WP_000611512.1 phage holin -
RK85_RS09485 1820004..1820759 + 756 WP_000861038.1 CHAP domain-containing protein -
RK85_RS09490 1820950..1821441 + 492 WP_000920037.1 staphylokinase -
RK85_RS09500 1822091..1822426 + 336 Protein_1776 SH3 domain-containing protein -
RK85_RS09505 1822521..1822970 - 450 WP_000727643.1 chemotaxis-inhibiting protein CHIPS -
RK85_RS09510 1823653..1824003 + 351 WP_000702262.1 complement inhibitor SCIN-A -
RK85_RS09515 1824056..1824316 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - groEL / hlb / sak / chp / scn 1765355..1824003 58648


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T93088 WP_011447039.1 NZ_CP026070:1819350-1819526 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T93088 NZ_CP026070:1819350-1819526 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 175 bp

>AT93088 NZ_CP026070:c1819688-1819514 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References