Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 1963763..1964070 Replicon chromosome
Accession NZ_CP012976
Organism Staphylococcus aureus strain ST20130942

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag SAST42_RS14380 Protein ID WP_011447039.1
Coordinates 1963894..1964070 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1963763..1963902 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST42_RS09735 1959106..1959366 + 261 WP_001791826.1 hypothetical protein -
SAST42_RS09740 1959419..1959769 - 351 WP_000702262.1 complement inhibitor SCIN-A -
SAST42_RS09745 1960450..1960899 + 450 WP_000727643.1 chemotaxis-inhibiting protein CHIPS -
SAST42_RS14695 1960994..1961329 - 336 Protein_1839 SH3 domain-containing protein -
SAST42_RS09755 1961979..1962470 - 492 WP_000920037.1 staphylokinase -
SAST42_RS09760 1962661..1963416 - 756 WP_000861038.1 CHAP domain-containing protein -
SAST42_RS09765 1963428..1963682 - 255 WP_000611512.1 phage holin -
SAST42_RS09770 1963734..1963841 + 108 WP_001791821.1 hypothetical protein -
- 1963763..1963902 + 140 NuclAT_0 - Antitoxin
- 1963763..1963902 + 140 NuclAT_0 - Antitoxin
- 1963763..1963902 + 140 NuclAT_0 - Antitoxin
- 1963763..1963902 + 140 NuclAT_0 - Antitoxin
SAST42_RS14380 1963894..1964070 - 177 WP_011447039.1 putative holin-like toxin Toxin
SAST42_RS09775 1964220..1964516 - 297 WP_000539688.1 DUF2951 domain-containing protein -
SAST42_RS09780 1964574..1964861 - 288 WP_062909805.1 hypothetical protein -
SAST42_RS09785 1964908..1965060 - 153 WP_001153681.1 hypothetical protein -
SAST42_RS09790 1965050..1968835 - 3786 WP_000582137.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / hlb / groEL 1959419..2016327 56908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T57562 WP_011447039.1 NZ_CP012976:c1964070-1963894 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T57562 NZ_CP012976:c1964070-1963894 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT57562 NZ_CP012976:1963763-1963902 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References