Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2036263..2036562 Replicon chromosome
Accession NZ_CP018205
Organism Staphylococcus aureus strain HG001 isolate RN1

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag BSR30_RS10715 Protein ID WP_011447039.1
Coordinates 2036386..2036562 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2036263..2036318 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSR30_RS10660 2031596..2031856 + 261 WP_001791826.1 hypothetical protein -
BSR30_RS10665 2031909..2032259 - 351 WP_000702262.1 complement inhibitor SCIN-A -
BSR30_RS10670 2032942..2033391 + 450 WP_000727643.1 chemotaxis-inhibiting protein CHIPS -
BSR30_RS15215 2033486..2033821 - 336 Protein_1966 SH3 domain-containing protein -
BSR30_RS10695 2034471..2034962 - 492 WP_000920037.1 staphylokinase -
BSR30_RS10700 2035153..2035908 - 756 WP_000861038.1 CHAP domain-containing protein -
BSR30_RS10705 2035920..2036174 - 255 WP_000611512.1 phage holin -
BSR30_RS10710 2036226..2036333 + 108 WP_001791821.1 hypothetical protein -
- 2036255..2036394 + 140 NuclAT_0 - -
- 2036255..2036394 + 140 NuclAT_0 - -
- 2036255..2036394 + 140 NuclAT_0 - -
- 2036255..2036394 + 140 NuclAT_0 - -
- 2036263..2036318 + 56 - - Antitoxin
BSR30_RS10715 2036386..2036562 - 177 WP_011447039.1 putative holin-like toxin Toxin
BSR30_RS10720 2036712..2037008 - 297 WP_000539688.1 DUF2951 domain-containing protein -
BSR30_RS10725 2037066..2037353 - 288 WP_001040261.1 hypothetical protein -
BSR30_RS10730 2037400..2037552 - 153 WP_001153681.1 hypothetical protein -
BSR30_RS10735 2037542..2041327 - 3786 WP_000582137.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / hlb / groEL 2031909..2087532 55623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T68904 WP_011447039.1 NZ_CP018205:c2036562-2036386 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T68904 NZ_CP018205:c2036562-2036386 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT68904 NZ_CP018205:2036263-2036318 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References