Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 98020..98319 Replicon chromosome
Accession NZ_CP026961
Organism Staphylococcus aureus strain FDAARGOS_10

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag RK68_RS00705 Protein ID WP_011447039.1
Coordinates 98143..98319 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 98020..98075 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK68_RS00660 93353..93613 + 261 WP_001791826.1 hypothetical protein -
RK68_RS00665 93666..94016 - 351 WP_000702262.1 complement inhibitor SCIN-A -
RK68_RS00670 94699..95148 + 450 WP_000727643.1 chemotaxis-inhibiting protein CHIPS -
RK68_RS00675 95243..95578 - 336 Protein_128 SH3 domain-containing protein -
RK68_RS00685 96228..96719 - 492 WP_000920037.1 staphylokinase -
RK68_RS00690 96910..97665 - 756 WP_000861038.1 CHAP domain-containing protein -
RK68_RS00695 97677..97931 - 255 WP_000611512.1 phage holin -
RK68_RS00700 97983..98090 + 108 WP_001791821.1 hypothetical protein -
- 98012..98151 + 140 NuclAT_0 - -
- 98012..98151 + 140 NuclAT_0 - -
- 98012..98151 + 140 NuclAT_0 - -
- 98012..98151 + 140 NuclAT_0 - -
- 98020..98075 + 56 - - Antitoxin
RK68_RS00705 98143..98319 - 177 WP_011447039.1 putative holin-like toxin Toxin
RK68_RS00710 98469..98765 - 297 WP_000539688.1 DUF2951 domain-containing protein -
RK68_RS00715 98823..99110 - 288 WP_001040261.1 hypothetical protein -
RK68_RS00720 99157..99309 - 153 WP_001153681.1 hypothetical protein -
RK68_RS00725 99299..103084 - 3786 WP_000582137.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / hlb / groEL 93666..149289 55623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T96846 WP_011447039.1 NZ_CP026961:c98319-98143 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T96846 NZ_CP026961:c98319-98143 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT96846 NZ_CP026961:98020-98075 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References