Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 1979373..1979680 Replicon chromosome
Accession NZ_LR133917
Organism Staphylococcus aureus strain NCTC8317

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag ELZ45_RS10105 Protein ID WP_011447039.1
Coordinates 1979504..1979680 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1979373..1979512 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ45_RS10060 1974714..1974974 + 261 WP_001791826.1 hypothetical protein -
ELZ45_RS10065 1975027..1975377 - 351 WP_000702262.1 complement inhibitor SCIN-A -
ELZ45_RS10070 1976060..1976509 + 450 WP_000727643.1 chemotaxis-inhibiting protein CHIPS -
ELZ45_RS10075 1976604..1976939 - 336 Protein_1861 SH3 domain-containing protein -
ELZ45_RS10085 1977589..1978080 - 492 WP_000920037.1 staphylokinase -
ELZ45_RS10090 1978271..1979026 - 756 WP_000861038.1 CHAP domain-containing protein -
ELZ45_RS10095 1979038..1979292 - 255 WP_000611512.1 phage holin -
ELZ45_RS10100 1979344..1979451 + 108 WP_001791821.1 hypothetical protein -
- 1979373..1979512 + 140 NuclAT_0 - Antitoxin
- 1979373..1979512 + 140 NuclAT_0 - Antitoxin
- 1979373..1979512 + 140 NuclAT_0 - Antitoxin
- 1979373..1979512 + 140 NuclAT_0 - Antitoxin
ELZ45_RS10105 1979504..1979680 - 177 WP_011447039.1 putative holin-like toxin Toxin
ELZ45_RS10110 1979830..1980126 - 297 WP_000539688.1 DUF2951 domain-containing protein -
ELZ45_RS10115 1980184..1980471 - 288 WP_001040261.1 hypothetical protein -
ELZ45_RS10120 1980518..1980670 - 153 WP_001153681.1 hypothetical protein -
ELZ45_RS10125 1980660..1984445 - 3786 WP_126497022.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - map / hlb / scn / chp / sak / hlb / groEL 1971533..2027773 56240
inside Prophage - scn / chp / sak / hlb / groEL 1975027..2027773 52746


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T286509 WP_011447039.1 NZ_LR133917:c1979680-1979504 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 140 bp

>AT286509 NZ_LR133917:1979373-1979512 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References