Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 1963769..1964076 Replicon chromosome
Accession NZ_CP012974
Organism Staphylococcus aureus strain ST20130943

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag SAST43_RS14375 Protein ID WP_011447039.1
Coordinates 1963900..1964076 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1963769..1963908 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST43_RS09735 1959111..1959371 + 261 WP_001791826.1 hypothetical protein -
SAST43_RS09740 1959424..1959774 - 351 WP_000702262.1 complement inhibitor SCIN-A -
SAST43_RS09745 1960456..1960905 + 450 WP_000727643.1 chemotaxis-inhibiting protein CHIPS -
SAST43_RS14695 1961000..1961335 - 336 Protein_1838 SH3 domain-containing protein -
SAST43_RS09755 1961985..1962476 - 492 WP_000920037.1 staphylokinase -
SAST43_RS09760 1962667..1963422 - 756 WP_000861038.1 CHAP domain-containing protein -
SAST43_RS09765 1963434..1963688 - 255 WP_000611512.1 phage holin -
SAST43_RS09770 1963740..1963847 + 108 WP_001791821.1 hypothetical protein -
- 1963769..1963908 + 140 NuclAT_0 - Antitoxin
- 1963769..1963908 + 140 NuclAT_0 - Antitoxin
- 1963769..1963908 + 140 NuclAT_0 - Antitoxin
- 1963769..1963908 + 140 NuclAT_0 - Antitoxin
SAST43_RS14375 1963900..1964076 - 177 WP_011447039.1 putative holin-like toxin Toxin
SAST43_RS09775 1964226..1964522 - 297 WP_000539688.1 DUF2951 domain-containing protein -
SAST43_RS09780 1964580..1964867 - 288 WP_062909805.1 hypothetical protein -
SAST43_RS09785 1964914..1965066 - 153 WP_001153681.1 hypothetical protein -
SAST43_RS09790 1965056..1968841 - 3786 WP_000582137.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / hlb / groEL 1959424..2016333 56909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T57547 WP_011447039.1 NZ_CP012974:c1964076-1963900 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T57547 NZ_CP012974:c1964076-1963900 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT57547 NZ_CP012974:1963769-1963908 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References