Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 93056..93363 Replicon chromosome
Accession NZ_CP026063
Organism Staphylococcus aureus strain FDAARGOS_14

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag RK72_RS00590 Protein ID WP_011447039.1
Coordinates 93187..93363 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 93056..93195 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK72_RS00545 88397..88657 + 261 WP_001791826.1 hypothetical protein -
RK72_RS00550 88710..89060 - 351 WP_000702262.1 complement inhibitor SCIN-A -
RK72_RS00555 89743..90192 + 450 WP_000727643.1 chemotaxis-inhibiting protein CHIPS -
RK72_RS00560 90287..90622 - 336 Protein_91 SH3 domain-containing protein -
RK72_RS00570 91272..91763 - 492 WP_000920041.1 staphylokinase -
RK72_RS00575 91954..92709 - 756 WP_000861038.1 CHAP domain-containing protein -
RK72_RS00580 92721..92975 - 255 WP_000611512.1 phage holin -
RK72_RS00585 93027..93134 + 108 WP_001791821.1 hypothetical protein -
- 93056..93195 + 140 NuclAT_0 - Antitoxin
- 93056..93195 + 140 NuclAT_0 - Antitoxin
- 93056..93195 + 140 NuclAT_0 - Antitoxin
- 93056..93195 + 140 NuclAT_0 - Antitoxin
RK72_RS00590 93187..93363 - 177 WP_011447039.1 putative holin-like toxin Toxin
RK72_RS00595 93513..93809 - 297 WP_000539688.1 DUF2951 domain-containing protein -
RK72_RS00600 93867..94154 - 288 WP_001040261.1 hypothetical protein -
RK72_RS00605 94201..94353 - 153 WP_001153681.1 hypothetical protein -
RK72_RS00610 94343..98128 - 3786 WP_000582137.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / hlb / groEL 88710..139328 50618


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T92974 WP_011447039.1 NZ_CP026063:c93363-93187 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T92974 NZ_CP026063:c93363-93187 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT92974 NZ_CP026063:93056-93195 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References