Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 1435600..1435899 Replicon chromosome
Accession NZ_AP017922
Organism Staphylococcus aureus strain JP02758

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag JP49775_RS06910 Protein ID WP_011447039.1
Coordinates 1435723..1435899 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 1435600..1435655 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JP49775_RS06865 1430933..1431193 + 261 WP_001791826.1 hypothetical protein -
JP49775_RS06870 1431246..1431596 - 351 WP_000702262.1 complement inhibitor SCIN-A -
JP49775_RS06875 1432279..1432728 + 450 WP_000727643.1 chemotaxis-inhibiting protein CHIPS -
JP49775_RS06880 1432823..1433158 - 336 Protein_1319 SH3 domain-containing protein -
JP49775_RS06890 1433808..1434299 - 492 WP_000920037.1 staphylokinase -
JP49775_RS06895 1434490..1435245 - 756 WP_000861038.1 CHAP domain-containing protein -
JP49775_RS06900 1435257..1435511 - 255 WP_000611512.1 phage holin -
JP49775_RS06905 1435563..1435670 + 108 WP_001791821.1 hypothetical protein -
- 1435592..1435731 + 140 NuclAT_0 - -
- 1435592..1435731 + 140 NuclAT_0 - -
- 1435592..1435731 + 140 NuclAT_0 - -
- 1435592..1435731 + 140 NuclAT_0 - -
- 1435600..1435655 + 56 - - Antitoxin
JP49775_RS06910 1435723..1435899 - 177 WP_011447039.1 putative holin-like toxin Toxin
JP49775_RS06915 1436049..1436345 - 297 WP_000539688.1 DUF2951 domain-containing protein -
JP49775_RS06920 1436403..1436690 - 288 WP_001040261.1 hypothetical protein -
JP49775_RS06925 1436737..1436889 - 153 WP_001153681.1 hypothetical protein -
JP49775_RS06930 1436879..1440664 - 3786 WP_149036335.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak 1431246..1475518 44272


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T31426 WP_011447039.1 NZ_AP017922:c1435899-1435723 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T31426 NZ_AP017922:c1435899-1435723 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT31426 NZ_AP017922:1435600-1435655 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References