Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2046091..2046390 Replicon chromosome
Accession NZ_LS483365
Organism Staphylococcus aureus subsp. aureus NCTC 8325

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DQM91_RS10740 Protein ID WP_011447039.1
Coordinates 2046214..2046390 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2046091..2046146 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM91_RS10695 2041424..2041684 + 261 WP_001791826.1 hypothetical protein -
DQM91_RS10700 2041737..2042087 - 351 WP_000702262.1 complement inhibitor SCIN-A -
DQM91_RS10705 2042770..2043219 + 450 WP_000727643.1 chemotaxis-inhibiting protein CHIPS -
DQM91_RS10710 2043314..2043649 - 336 Protein_1974 SH3 domain-containing protein -
DQM91_RS10720 2044299..2044790 - 492 WP_000920037.1 staphylokinase -
DQM91_RS10725 2044981..2045736 - 756 WP_000861038.1 CHAP domain-containing protein -
DQM91_RS10730 2045748..2046002 - 255 WP_000611512.1 phage holin -
DQM91_RS10735 2046054..2046161 + 108 WP_001791821.1 hypothetical protein -
- 2046083..2046222 + 140 NuclAT_0 - -
- 2046083..2046222 + 140 NuclAT_0 - -
- 2046083..2046222 + 140 NuclAT_0 - -
- 2046083..2046222 + 140 NuclAT_0 - -
- 2046091..2046146 + 56 - - Antitoxin
DQM91_RS10740 2046214..2046390 - 177 WP_011447039.1 putative holin-like toxin Toxin
DQM91_RS10745 2046540..2046836 - 297 WP_000539688.1 DUF2951 domain-containing protein -
DQM91_RS10750 2046894..2047181 - 288 WP_001040261.1 hypothetical protein -
DQM91_RS10755 2047228..2047380 - 153 WP_001153681.1 hypothetical protein -
DQM91_RS10760 2047370..2051155 - 3786 WP_000582137.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / hlb / groEL 2041737..2097360 55623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T292434 WP_011447039.1 NZ_LS483365:c2046390-2046214 [Staphylococcus aureus subsp. aureus NCTC 8325]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT292434 NZ_LS483365:2046091-2046146 [Staphylococcus aureus subsp. aureus NCTC 8325]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References