46477

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 1887968..1888306 Replicon chromosome
Accession NZ_CP007454
Organism Staphylococcus aureus strain 502A isolate RN6607

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag CH52_RS14650 Protein ID WP_011447039.1
Coordinates 1887968..1888144 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1888132..1888306 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH52_RS09570 1883203..1886988 + 3786 WP_000582137.1 hypothetical protein -
CH52_RS09575 1886978..1887130 + 153 WP_001153681.1 hypothetical protein -
CH52_RS09580 1887177..1887464 + 288 WP_001040261.1 hypothetical protein -
CH52_RS09585 1887522..1887818 + 297 WP_000539688.1 DUF2951 domain-containing protein -
CH52_RS14650 1887968..1888144 + 177 WP_011447039.1 putative holin-like toxin Toxin
- 1888132..1888306 - 175 - - Antitoxin
CH52_RS09600 1888356..1888610 + 255 WP_000611512.1 phage holin -
CH52_RS09605 1888622..1889377 + 756 WP_000861038.1 CHAP domain-containing protein -
CH52_RS09610 1889568..1890059 + 492 WP_000920041.1 staphylokinase -
CH52_RS14905 1890709..1891044 + 336 Protein_1841 SH3 domain-containing protein -
CH52_RS09620 1891139..1891588 - 450 WP_000727643.1 chemotaxis-inhibiting protein CHIPS -
CH52_RS09625 1892271..1892621 + 351 WP_000702262.1 complement inhibitor SCIN-A -
CH52_RS09630 1892674..1892934 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - hlb / sak / chp / scn 1846270..1892621 46351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T46477 WP_011447039.1 NZ_CP007454:1887968-1888144 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T46477 NZ_CP007454:1887968-1888144 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 175 bp

>AT46477 NZ_CP007454:c1888306-1888132 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References