Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/- |
| Location | 1933297..1933879 | Replicon | chromosome |
| Accession | NC_010424 | ||
| Organism | Candidatus Desulforudis audaxviator MP104C | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | B1I5M6 |
| Locus tag | DAUD_RS09255 | Protein ID | WP_012302900.1 |
| Coordinates | 1933297..1933653 (-) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | - |
| Locus tag | DAUD_RS09260 | Protein ID | WP_200858705.1 |
| Coordinates | 1933643..1933879 (-) | Length | 79 a.a. |
Genomic Context
Location: 1934074..1934550 (477 bp)
Type: Others
Protein ID: WP_012302902.1
Type: Others
Protein ID: WP_012302902.1
Location: 1934499..1935149 (651 bp)
Type: Others
Protein ID: WP_083756655.1
Type: Others
Protein ID: WP_083756655.1
Location: 1935794..1936735 (942 bp)
Type: Others
Protein ID: WP_012302904.1
Type: Others
Protein ID: WP_012302904.1
Location: 1936758..1937111 (354 bp)
Type: Others
Protein ID: WP_012302905.1
Type: Others
Protein ID: WP_012302905.1
Location: 1937108..1937551 (444 bp)
Type: Others
Protein ID: WP_041570926.1
Type: Others
Protein ID: WP_041570926.1
Location: 1928930..1929844 (915 bp)
Type: Others
Protein ID: WP_012302896.1
Type: Others
Protein ID: WP_012302896.1
Location: 1930023..1930403 (381 bp)
Type: Others
Protein ID: WP_012302897.1
Type: Others
Protein ID: WP_012302897.1
Location: 1930410..1930583 (174 bp)
Type: Others
Protein ID: Protein_1864
Type: Others
Protein ID: Protein_1864
Location: 1930594..1931487 (894 bp)
Type: Others
Protein ID: WP_166485173.1
Type: Others
Protein ID: WP_166485173.1
Location: 1931738..1931947 (210 bp)
Type: Others
Protein ID: WP_041570924.1
Type: Others
Protein ID: WP_041570924.1
Location: 1931947..1932126 (180 bp)
Type: Others
Protein ID: WP_166485174.1
Type: Others
Protein ID: WP_166485174.1
Location: 1932248..1932415 (168 bp)
Type: Others
Protein ID: WP_166485175.1
Type: Others
Protein ID: WP_166485175.1
Location: 1932412..1932741 (330 bp)
Type: Others
Protein ID: WP_012302899.1
Type: Others
Protein ID: WP_012302899.1
Location: 1932731..1933288 (558 bp)
Type: Others
Protein ID: WP_083756654.1
Type: Others
Protein ID: WP_083756654.1
Location: 1933297..1933653 (357 bp)
Type: Toxin
Protein ID: WP_012302900.1
Type: Toxin
Protein ID: WP_012302900.1
Location: 1933643..1933879 (237 bp)
Type: Antitoxin
Protein ID: WP_200858705.1
Type: Antitoxin
Protein ID: WP_200858705.1
Location: 1935484..1935648 (165 bp)
Type: Others
Protein ID: WP_166485176.1
Type: Others
Protein ID: WP_166485176.1
Location: 1937636..1937881 (246 bp)
Type: Others
Protein ID: WP_012302907.1
Type: Others
Protein ID: WP_012302907.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DAUD_RS09220 (Daud_1824) | 1928930..1929844 | - | 915 | WP_012302896.1 | putative DNA binding domain-containing protein | - |
| DAUD_RS09225 (Daud_1825) | 1930023..1930403 | - | 381 | WP_012302897.1 | hypothetical protein | - |
| DAUD_RS09230 (Daud_1826) | 1930410..1930583 | - | 174 | Protein_1864 | DUF1887 domain-containing protein | - |
| DAUD_RS09235 (Daud_1827) | 1930594..1931487 | - | 894 | WP_166485173.1 | CRISPR-associated protein Csx14 | - |
| DAUD_RS09240 (Daud_1828) | 1931738..1931947 | - | 210 | WP_041570924.1 | 4Fe-4S binding protein | - |
| DAUD_RS12560 | 1931947..1932126 | - | 180 | WP_166485174.1 | hypothetical protein | - |
| DAUD_RS12565 | 1932248..1932415 | - | 168 | WP_166485175.1 | hypothetical protein | - |
| DAUD_RS09245 (Daud_1829) | 1932412..1932741 | - | 330 | WP_012302899.1 | helix-turn-helix domain-containing protein | - |
| DAUD_RS09250 (Daud_1830) | 1932731..1933288 | - | 558 | WP_083756654.1 | hypothetical protein | - |
| DAUD_RS09255 (Daud_1831) | 1933297..1933653 | - | 357 | WP_012302900.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| DAUD_RS09260 (Daud_1832) | 1933643..1933879 | - | 237 | WP_200858705.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| DAUD_RS09265 (Daud_1833) | 1934074..1934550 | + | 477 | WP_012302902.1 | hypothetical protein | - |
| DAUD_RS09270 (Daud_1834) | 1934499..1935149 | + | 651 | WP_083756655.1 | hypothetical protein | - |
| DAUD_RS12570 | 1935484..1935648 | - | 165 | WP_166485176.1 | hypothetical protein | - |
| DAUD_RS09280 (Daud_1835) | 1935794..1936735 | + | 942 | WP_012302904.1 | hypothetical protein | - |
| DAUD_RS11685 (Daud_1836) | 1936758..1937111 | + | 354 | WP_012302905.1 | EscU/YscU/HrcU family type III secretion system export apparatus switch protein | - |
| DAUD_RS09290 (Daud_1837) | 1937108..1937551 | + | 444 | WP_041570926.1 | ribonuclease HI | - |
| DAUD_RS09295 (Daud_1838) | 1937636..1937881 | - | 246 | WP_012302907.1 | hypothetical protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12642.52 Da Isoelectric Point: 8.9971
>T10042 WP_012302900.1 NC_010424:c1933653-1933297 [Candidatus Desulforudis audaxviator MP104C]
VEIKRGDVFLVNFNPARGSEQAGCRPAVVVQNDVGNKYGPTTIVIAVTTTLKDYPFLVKLSAGEGGLEKDSTANAAQVLT
VDKLRLVRKLGNLTSEKMREINRALAVSLGLTLGETQD
VEIKRGDVFLVNFNPARGSEQAGCRPAVVVQNDVGNKYGPTTIVIAVTTTLKDYPFLVKLSAGEGGLEKDSTANAAQVLT
VDKLRLVRKLGNLTSEKMREINRALAVSLGLTLGETQD
Download Length: 357 bp
>T10042 NC_010424:c1933653-1933297 [Candidatus Desulforudis audaxviator MP104C]
GTGGAGATTAAACGTGGCGATGTTTTCCTGGTGAACTTTAACCCGGCGCGGGGAAGTGAGCAGGCGGGCTGTCGGCCCGC
CGTCGTCGTTCAAAACGATGTGGGCAACAAGTATGGCCCAACCACAATTGTGATCGCAGTGACCACTACTCTCAAGGATT
ACCCCTTCCTGGTGAAGTTAAGCGCTGGAGAAGGGGGACTGGAGAAAGACAGCACGGCCAATGCCGCCCAGGTGTTGACC
GTGGACAAGTTGCGCTTGGTGCGCAAGCTGGGGAATCTCACTTCAGAGAAAATGCGCGAGATAAATCGGGCGCTGGCGGT
GAGCCTTGGGTTGACTCTCGGAGAGACCCAGGATTAA
GTGGAGATTAAACGTGGCGATGTTTTCCTGGTGAACTTTAACCCGGCGCGGGGAAGTGAGCAGGCGGGCTGTCGGCCCGC
CGTCGTCGTTCAAAACGATGTGGGCAACAAGTATGGCCCAACCACAATTGTGATCGCAGTGACCACTACTCTCAAGGATT
ACCCCTTCCTGGTGAAGTTAAGCGCTGGAGAAGGGGGACTGGAGAAAGACAGCACGGCCAATGCCGCCCAGGTGTTGACC
GTGGACAAGTTGCGCTTGGTGCGCAAGCTGGGGAATCTCACTTCAGAGAAAATGCGCGAGATAAATCGGGCGCTGGCGGT
GAGCCTTGGGTTGACTCTCGGAGAGACCCAGGATTAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8713.96 Da Isoelectric Point: 5.6957
>AT10042 WP_200858705.1 NC_010424:c1933879-1933643 [Candidatus Desulforudis audaxviator MP104C]
VNAKIAVSLPEQLLSVLDSLARKWATTRSGAVAELLRRAEQEELEVRLRQGYLEMAELHKAHAELFLPSQAEVFRGGD
VNAKIAVSLPEQLLSVLDSLARKWATTRSGAVAELLRRAEQEELEVRLRQGYLEMAELHKAHAELFLPSQAEVFRGGD
Download Length: 237 bp
>AT10042 NC_010424:c1933879-1933643 [Candidatus Desulforudis audaxviator MP104C]
GTGAACGCGAAAATCGCCGTAAGTTTGCCGGAACAGCTTCTCTCCGTTTTGGATTCCTTGGCCCGGAAATGGGCCACCAC
CAGAAGCGGCGCTGTAGCCGAGCTGCTGCGGCGTGCGGAGCAGGAGGAGCTGGAGGTCCGGCTCAGGCAAGGCTATCTTG
AAATGGCGGAGCTTCACAAAGCCCACGCCGAGCTTTTCCTTCCGTCGCAAGCAGAGGTGTTTCGCGGTGGAGATTAA
GTGAACGCGAAAATCGCCGTAAGTTTGCCGGAACAGCTTCTCTCCGTTTTGGATTCCTTGGCCCGGAAATGGGCCACCAC
CAGAAGCGGCGCTGTAGCCGAGCTGCTGCGGCGTGCGGAGCAGGAGGAGCTGGAGGTCCGGCTCAGGCAAGGCTATCTTG
AAATGGCGGAGCTTCACAAAGCCCACGCCGAGCTTTTCCTTCCGTCGCAAGCAGAGGTGTTTCGCGGTGGAGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10096 | Clostridium difficile R20291 | 46.429 | 94.915 | 0.441 |
| T10094 | Staphylococcus aureus strain HG003 isolate RN1 Scaffold_3 | 46.847 | 94.068 | 0.441 |
| T612 | Staphylococcus aureus subsp. aureus MW2 | 46.847 | 94.068 | 0.441 |
| T10078 | Staphylococcus aureus strain HG003 isolate RN1 Scaffold_3 | 46.847 | 94.068 | 0.441 |
| T10177 | Staphylococcus epidermidis isolate BPH0662 | 46.847 | 94.068 | 0.441 |
| T1073 | Staphylococcus aureus subsp. aureus N315 | 46.847 | 94.068 | 0.441 |
| T6140 | Lactobacillus rhamnosus GG | 45.133 | 95.763 | 0.432 |
| T6135 | Lactobacillus rhamnosus GG | 45.133 | 95.763 | 0.432 |
| T6136 | Lactobacillus rhamnosus Lc 705 | 45.133 | 95.763 | 0.432 |
| T6141 | Lactobacillus rhamnosus ATCC 8530 | 45.133 | 95.763 | 0.432 |
Multiple sequence alignment
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT10101 | Nitrospira sp. ND1 isolate Nitrospira sp. strain ND1 | 32.407 | 99.083 | 0.321 |
Showing 1 to 1 of 1 rows
Multiple sequence alignment
Structures
Toxin
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Source | ID | Structure |
|---|---|---|
| AlphaFold DB | B1I5M6 |
Antitoxin
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Source | ID | Structure |
|---|---|---|
| No matching records found | ||
References
(1) Hiroko Tamiya-Ishitsuka et al. (2021) Conserved Amino Acid Moieties of Candidatus Desulforudis audaxviator MazF Determine Ribonuclease Activity and Specificity. Frontiers in Microbiology 12:748619. [PubMed:34867867]