Detailed information    

insolico Bioinformatically predicted

Overview


Name   comX/sigX   Type   Regulator
Locus tag   QN282_RS00130 Genome accession   NZ_CP134689
Coordinates   10676..11155 (+) Length   159 a.a.
NCBI ID   WP_001204194.1    Uniprot ID   A0AAV3JNR5
Organism   Streptococcus agalactiae strain HU05/19     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 11334..60137 10676..11155 flank 179
IScluster/Tn 9195..10000 10676..11155 flank 676


Gene organization within MGE regions


Location: 9195..60137
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QN282_RS00125 (QN282_00125) - 10057..10476 (+) 420 WP_000784700.1 YjdF family protein -
  QN282_RS00130 (QN282_00130) comX/sigX 10676..11155 (+) 480 WP_001204194.1 sigma-70 family RNA polymerase sigma factor Regulator
  QN282_RS00135 (QN282_00135) - 11334..12431 (-) 1098 WP_000570847.1 site-specific integrase -
  QN282_RS00140 (QN282_00140) - 12612..13238 (-) 627 WP_000438040.1 TrbC/VirB2 family protein -
  QN282_RS00145 (QN282_00145) - 13290..13670 (-) 381 WP_041981104.1 ImmA/IrrE family metallo-endopeptidase -
  QN282_RS00150 (QN282_00150) - 13660..14019 (-) 360 WP_000207087.1 helix-turn-helix domain-containing protein -
  QN282_RS00155 (QN282_00155) - 14398..14541 (+) 144 WP_001113676.1 hypothetical protein -
  QN282_RS00160 (QN282_00160) - 14661..14843 (-) 183 WP_000274022.1 YegP family protein -
  QN282_RS00165 (QN282_00165) - 14901..15059 (+) 159 WP_001104146.1 hypothetical protein -
  QN282_RS00170 (QN282_00170) - 15206..15901 (-) 696 WP_000039331.1 hypothetical protein -
  QN282_RS00175 (QN282_00175) - 15956..16165 (+) 210 WP_001247539.1 hypothetical protein -
  QN282_RS00180 (QN282_00180) - 16154..16540 (-) 387 WP_000460827.1 hypothetical protein -
  QN282_RS00185 (QN282_00185) - 16780..17115 (-) 336 WP_000360289.1 hypothetical protein -
  QN282_RS00190 (QN282_00190) - 17191..17391 (+) 201 WP_001875236.1 helix-turn-helix transcriptional regulator -
  QN282_RS00195 (QN282_00195) - 17439..18167 (+) 729 Protein_19 phage antirepressor KilAC domain-containing protein -
  QN282_RS00200 (QN282_00200) - 18220..18357 (+) 138 WP_000627309.1 hypothetical protein -
  QN282_RS00205 (QN282_00205) - 18484..18630 (+) 147 WP_001867241.1 hypothetical protein -
  QN282_RS00210 (QN282_00210) - 18593..18901 (-) 309 WP_001000651.1 hypothetical protein -
  QN282_RS00215 (QN282_00215) - 19011..19268 (+) 258 WP_016480517.1 hypothetical protein -
  QN282_RS00220 (QN282_00220) - 19297..19521 (+) 225 WP_000431164.1 hypothetical protein -
  QN282_RS00225 (QN282_00225) - 19555..20088 (+) 534 WP_264402120.1 hypothetical protein -
  QN282_RS00230 (QN282_00230) - 20172..20525 (+) 354 WP_264402119.1 helix-turn-helix domain-containing protein -
  QN282_RS00235 (QN282_00235) - 20608..20922 (+) 315 WP_000135595.1 hypothetical protein -
  QN282_RS00240 (QN282_00240) - 20909..21601 (+) 693 WP_000704953.1 AAA family ATPase -
  QN282_RS00245 (QN282_00245) - 21588..22931 (+) 1344 WP_000776547.1 DEAD/DEAH box helicase -
  QN282_RS00250 (QN282_00250) - 22947..23408 (+) 462 WP_000494143.1 DUF669 domain-containing protein -
  QN282_RS00255 (QN282_00255) - 23412..24215 (+) 804 WP_000250451.1 bifunctional DNA primase/polymerase -
  QN282_RS00260 (QN282_00260) - 24208..25725 (+) 1518 WP_000564707.1 DNA primase family protein -
  QN282_RS00265 (QN282_00265) - 25969..26295 (+) 327 WP_000206193.1 VRR-NUC domain-containing protein -
  QN282_RS00270 (QN282_00270) - 26276..26621 (+) 346 Protein_34 hypothetical protein -
  QN282_RS00275 (QN282_00275) - 26633..26920 (+) 288 WP_000130094.1 nucleotide modification associated domain-containing protein -
  QN282_RS00280 (QN282_00280) - 26904..27311 (+) 408 WP_000612386.1 YopX family protein -
  QN282_RS00285 (QN282_00285) - 27435..27578 (+) 144 WP_000564611.1 hypothetical protein -
  QN282_RS00290 (QN282_00290) - 27575..28075 (+) 501 WP_060458033.1 DUF1642 domain-containing protein -
  QN282_RS00295 (QN282_00295) - 28096..28395 (+) 300 WP_001105090.1 hypothetical protein -
  QN282_RS00300 (QN282_00300) - 28583..28777 (+) 195 WP_000221698.1 hypothetical protein -
  QN282_RS00305 (QN282_00305) - 28774..29040 (+) 267 WP_000660738.1 hypothetical protein -
  QN282_RS00310 (QN282_00310) - 29430..29864 (+) 435 WP_000142570.1 ArpU family phage packaging/lysis transcriptional regulator -
  QN282_RS00315 (QN282_00315) - 30587..31084 (+) 498 WP_079261306.1 terminase small subunit -
  QN282_RS00320 (QN282_00320) - 31071..32312 (+) 1242 WP_000423579.1 PBSX family phage terminase large subunit -
  QN282_RS00325 (QN282_00325) - 32325..33818 (+) 1494 WP_000930110.1 phage portal protein -
  QN282_RS00330 (QN282_00330) - 33802..34773 (+) 972 WP_000367179.1 minor capsid protein -
  QN282_RS00335 (QN282_00335) - 34770..34973 (+) 204 WP_001042289.1 hypothetical protein -
  QN282_RS00340 (QN282_00340) - 35084..35662 (+) 579 WP_000774603.1 DUF4355 domain-containing protein -
  QN282_RS00345 (QN282_00345) - 35672..36055 (+) 384 WP_001042769.1 head decoration protein -
  QN282_RS00350 (QN282_00350) - 36055..37107 (+) 1053 WP_001185214.1 major capsid protein -
  QN282_RS00355 (QN282_00355) - 37120..37374 (+) 255 WP_001229661.1 HeH/LEM domain-containing protein -
  QN282_RS00360 (QN282_00360) - 37390..37743 (+) 354 WP_000411527.1 phage head-tail connector protein -
  QN282_RS00365 (QN282_00365) - 37740..38039 (+) 300 WP_001270064.1 hypothetical protein -
  QN282_RS00370 (QN282_00370) - 38032..38412 (+) 381 WP_000609259.1 HK97-gp10 family putative phage morphogenesis protein -
  QN282_RS00375 (QN282_00375) - 38409..38798 (+) 390 WP_000977637.1 DUF3168 domain-containing protein -
  QN282_RS00380 (QN282_00380) - 38807..39334 (+) 528 WP_000258802.1 phage major tail protein, TP901-1 family -
  QN282_RS00385 (QN282_00385) - 39409..39762 (+) 354 WP_000659174.1 tail assembly chaperone -
  QN282_RS00390 (QN282_00390) - 39882..40157 (+) 276 WP_000218309.1 hypothetical protein -
  QN282_RS00395 (QN282_00395) - 40150..42798 (+) 2649 WP_000071276.1 phage tail tape measure protein -
  QN282_RS00400 (QN282_00400) - 42799..44361 (+) 1563 WP_049447604.1 distal tail protein Dit -
  QN282_RS00405 (QN282_00405) - 44352..48479 (+) 4128 WP_410531116.1 glucosaminidase domain-containing protein -
  QN282_RS00410 (QN282_00410) - 48492..50483 (+) 1992 WP_410531117.1 DUF859 family phage minor structural protein -
  QN282_RS00415 (QN282_00415) - 50497..50823 (+) 327 WP_000404431.1 DUF1366 domain-containing protein -
  QN282_RS00420 (QN282_00420) - 50798..51010 (+) 213 WP_000698337.1 hypothetical protein -
  QN282_RS00425 (QN282_00425) - 51023..51325 (+) 303 WP_000215499.1 hypothetical protein -
  QN282_RS00430 (QN282_00430) - 51327..51581 (+) 255 WP_000611524.1 phage holin -
  QN282_RS00435 (QN282_00435) - 51707..53041 (+) 1335 WP_410531118.1 GH25 family lysozyme -
  QN282_RS00440 (QN282_00440) - 53171..54067 (+) 897 WP_001061853.1 sensor histidine kinase -
  QN282_RS00445 (QN282_00445) - 54061..54360 (+) 300 WP_000258211.1 STAS-like domain-containing protein -
  QN282_RS00450 (QN282_00450) - 54470..54670 (+) 201 WP_000076712.1 CsbD family protein -
  QN282_RS00455 (QN282_00455) - 54751..55002 (-) 252 WP_050196899.1 hypothetical protein -
  QN282_RS00460 (QN282_00460) - 55142..55288 (-) 147 WP_001030870.1 hypothetical protein -
  QN282_RS00465 (QN282_00465) - 55439..55648 (+) 210 WP_000424774.1 helix-turn-helix domain-containing protein -
  QN282_RS00470 (QN282_00470) - 55731..56555 (+) 825 WP_001125980.1 DUF3825 domain-containing protein -
  QN282_RS00475 (QN282_00475) - 56922..57467 (+) 546 WP_001870774.1 exotoxin beta-grasp domain-containing protein -
  QN282_RS00480 (QN282_00480) prx 57729..57911 (+) 183 WP_000965649.1 hypothetical protein Regulator
  QN282_RS00485 (QN282_00485) - 58124..58816 (+) 693 WP_000049272.1 histidine phosphatase family protein -
  QN282_RS00490 (QN282_00490) - 58813..59565 (+) 753 WP_000739660.1 M15 family metallopeptidase -
  QN282_RS00495 (QN282_00495) - 59562..60137 (+) 576 WP_001231504.1 glycoside hydrolase family 73 protein -

Sequence


Protein


Download         Length: 159 a.a.        Molecular weight: 19447.28 Da        Isoelectric Point: 6.2639

>NTDB_id=882784 QN282_RS00130 WP_001204194.1 10676..11155(+) (comX/sigX) [Streptococcus agalactiae strain HU05/19]
MRDFEELFDKVKPIVMKLRRNYFVQLWEYDDWIQEGRIVLFRLLEEHPYLLDNESKLFIYFKTKFSNYLNDVLRHQDCQK
RQFNKMPYEEISEVSHYVKSKGLVLDDYIAYRDTLTKVEETLSDIDKEKFEKLISGERFAGKKQFIRDIQPFFNAFKAD

Nucleotide


Download         Length: 480 bp        

>NTDB_id=882784 QN282_RS00130 WP_001204194.1 10676..11155(+) (comX/sigX) [Streptococcus agalactiae strain HU05/19]
TTGAGAGATTTTGAGGAGTTGTTTGATAAAGTAAAGCCAATCGTAATGAAGCTGAGAAGAAATTATTTTGTTCAACTTTG
GGAATATGATGATTGGATTCAAGAAGGACGTATTGTACTTTTTAGGTTGCTTGAAGAGCATCCGTATTTATTGGATAATG
AAAGCAAACTATTCATTTACTTTAAAACAAAATTTTCAAATTATTTAAACGATGTATTAAGACACCAAGATTGTCAAAAG
CGACAATTTAATAAAATGCCTTATGAAGAAATAAGTGAAGTTAGTCACTATGTTAAGAGTAAAGGACTAGTTTTAGATGA
CTATATTGCTTATCGTGATACTTTAACAAAAGTGGAAGAAACTTTGTCAGATATTGATAAAGAAAAATTTGAAAAACTGA
TTAGTGGTGAACGTTTTGCGGGGAAGAAACAATTCATACGAGATATTCAACCCTTTTTCAATGCTTTTAAAGCGGATTAA

Domains



No domain identified.



Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

56.688

98.742

0.56

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

52.349

93.711

0.491

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

52.349

93.711

0.491

  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

52.349

93.711

0.491

  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

52.349

93.711

0.491

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

52

94.34

0.491

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

52

94.34

0.491

  comX/sigX Streptococcus mutans UA159

49.677

97.484

0.484

  comX Streptococcus sobrinus strain NIDR 6715-7

43.59

98.113

0.428

  comX/sigX Streptococcus suis D9

43.226

97.484

0.421

  comX/sigX Streptococcus suis isolate S10

43.226

97.484

0.421

  comX/sigX Streptococcus suis P1/7

43.226

97.484

0.421

  comX Streptococcus thermophilus LMD-9

42.177

92.453

0.39

  comX Streptococcus thermophilus LMG 18311

42.177

92.453

0.39

  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

39.869

96.226

0.384

  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

39.869

96.226

0.384

  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

39.869

96.226

0.384

  comX/comX2 Streptococcus pneumoniae Rx1

40.397

94.969

0.384

  comX/comX2 Streptococcus pneumoniae TIGR4

40.397

94.969

0.384

  comX/comX1 Streptococcus pneumoniae TIGR4

40.397

94.969

0.384

  comX/comX1 Streptococcus pneumoniae Rx1

40.397

94.969

0.384

  comX/comX2 Streptococcus pneumoniae D39

40.397

94.969

0.384

  comX/comX1 Streptococcus pneumoniae D39

40.397

94.969

0.384

  comX/comX2 Streptococcus pneumoniae R6

40.397

94.969

0.384

  comX/comX1 Streptococcus pneumoniae R6

40.397

94.969

0.384

  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

39.216

96.226

0.377

  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

39.216

96.226

0.377

  comX Streptococcus salivarius SK126

40.816

92.453

0.377

  comX/sigX Streptococcus salivarius strain HSISS4

40.816

92.453

0.377

  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

38.562

96.226

0.371